Results 71 to 80 of about 226,052 (275)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Algorithms, 2022 Deep neural networks (DNNs) are sensitive to adversarial data in a variety of scenarios, including the black-box scenario, where the attacker is only allowed to query the trained model and receive an output.
Raz Lapid, Zvika Haramaty, Moshe Sipper
doaj +1 more source
Optimal Black-Box Reductions Between Optimization Objectives
, 2016 The diverse world of machine learning applications has given rise to a plethora of algorithms and optimization methods, finely tuned to the specific regression or classification task at hand. We reduce the complexity of algorithm design for machine learning by reductions: we develop reductions that take a method developed for one setting and apply it ...
Allen-Zhu, Zeyuan, Hazan, Elad
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Machine–Learning in Optimization of Expensive Black–Box Functions
International Journal of Applied Mathematics and Computer Science, 2017 Modern engineering design optimization often uses computer simulations to evaluate candidate designs. For some of these designs the simulation can fail for an unknown reason, which in turn may hamper the optimization process.
Tenne Yoel
doaj +1 more source
Hdconfigor: Automatically Tuning High Dimensional Configuration Parameters for Log Search Engines
IEEE Access, 2020 Search engines are nowadays widely applied to store and analyze logs generated by large-scale distributed systems. To adapt to various workload scenarios, log search engines such as Elasticsearch usually expose a large number of performance-related ...
Hui Dou, Pengfei Chen, Zibin Zheng
doaj +1 more source
IEEE Access, 2021 A modeling and parameter identification method for rate dependent hysteresis of piezoelectric actuated nano-stage is presented in this work. A system level quasi-static hysteresis model is employed to construct a neural network.
Khubab Ahmed, Peng Yan
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source