Results 91 to 100 of about 491,360 (284)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Recovery Strategies for Combined Optical Storage Systems Based on System Short-Circuit Ratio (SCR) Thresholds

Energies
The penetration rate of variable energy sources in the current power grid is increasing, with the aim being to expand the use of these energy sources and to replace the traditional black start power supply.
Qingji Yang, Baohong Li, Qin Jiang, Qiao Peng   +3 more
doaj   +1 more source

A Novel Sectionalizing Method for Power System Parallel Restoration Based on Minimum Spanning Tree

Energies, 2017
Parallel restoration is a way to accelerate the black-start procedure of power systems following a blackout. An efficient sectionalizing scheme can reduce the restoration time of a system, taking into account the black-start ability, generation-load ...
Changcheng Li, Jinghan He, Pei Zhang, Yin Xu   +3 more
doaj   +1 more source

New insights into the evolution of the FR I radio galaxy 3C 270 (NGC 4261) from VLA and GMRT radio observations

, 2015
We present Giant Metrewave Radio Telescope (GMRT) 240 MHz observations of the nearby luminous FR I radio source 3C 270, in the group-central elliptical NGC 4261.
Birkinshaw, Mark, Giacintucci, Simona, Ishwara-Chandra, C. H., Kolokythas, Konstantinos, O'Sullivan, Ewan, Raychaudhury, Somak, Worrall, Diana M.   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development of a Sequential Restoration Strategy Based on the Enhanced Dijkstra Algorithm for Korean Power Systems

Applied Sciences, 2016
When a blackout occurs, it is important to reduce the time for power system restoration to minimize damage. For fast restoration, it is important to reduce taking time for the selection of generators, transmission lines and transformers.
Bokyung Goo, Solyoung Jung, Jin Hur
doaj   +1 more source

A review of microgrid development in the United States – A decade of progress on policies, demonstrations, controls, and software tools [PDF]

, 2018
Microgrids have become increasingly popular in the United States. Supported by favorable federal and local policies, microgrid projects can provide greater energy stability and resilience within a project site or community.
Bao, Y, Feng, W, Jin, M, Liu, X, Marnay, C, Yao, C, Yu, J   +6 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source