Results 31 to 40 of about 46,241 (258)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Effects of Aversive Conditioning on Behavior of Nuisance Louisiana Black Bears
Human-Wildlife Interactions, 2017 Complaints associated with nuisance activity by Louisiana black bears (Ursus americanus luteolus) in south Louisiana have steadily increased since 2000, demanding intervention by state and federal agencies.
Jennifer Leigh, Michael J. Chamberlain
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Black bear population reduction and recovery in western Interior Alaska
Wildlife Society Bulletin, 2014 We documented the temporal and demographic recovery of a black bear (Ursus americanus) population following a 2‐year translocation program that substantially reduced both male and female bears. We estimated black bear population abundance prior to (2003),
Mark A. Keech +3 more
doaj +1 more source
PLoS ONE, 2021 Black bears (Ursus americanus) are an iconic and common species throughout much of the United States and people regularly interact with these large predators without conflict.
Jason S Hagani +4 more
doaj +1 more source
Building Bear Fences for Your Apiary
EDIS, 2021 The American black bear is beloved, but it is also the most damaging vertebrate pest of honey bee apiaries in North America. That is in part because bears and beekeepers often share the same home territory.
Kimberly K. Post, Cameron Jack
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
PLoS ONE, 2018 Asiatic black bears (Ursus thibetanus) have a widespread distribution in mountain landscapes, and are considered vulnerable globally, but are low-priority species for conservation in Nepal.
Rabin Kadariya +5 more
doaj +1 more source