Results 101 to 110 of about 2,527,813 (283)

Let's open agriculture's black box

California Agriculture, 1977
California Agriculture - All ...
J Kendrick
doaj  

Black Box Warning by the United States Food and Drug Administration: The Impact on the Dispensing Rate of Benzodiazepines

Pharmacoepidemiology
Background/objectives: In 9/2020, the United States Food and Drug Administration )FDA( posted a black box warning for all benzodiazepines, addressing their association with serious risks of abuse, addiction, physical dependence, and withdrawal reactions.
Neta Shanwetter Levit, Keren Filosof, Jacob Glazer, Daniel A. Goldstein   +3 more
doaj   +1 more source

Modelling a hydrologic Black-Box

Tecnología y ciencias del agua, 2018
Stella, J. M., & Warner, G. S. (January-February, 2018). Modelling a hydrologic Black-Box. Water Technology and Sciences (in Spanish), 9(1), 101-112, DOI: 10.24850/j-tyca-2018-01-07.
Juan M. Stella, Glenn S. Warner
doaj   +1 more source

Black-Box Forgetting

Advances in Neural Information Processing Systems 37
Large-scale pre-trained models (PTMs) provide remarkable zero-shot classification capability covering a wide variety of object classes. However, practical applications do not always require the classification of all kinds of objects, and leaving the model capable of recognizing unnecessary classes not only degrades overall accuracy but also leads to ...
Yusuke Kuwana, Yuta Goto, Takashi Shibata 0001, Go Irie   +3 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Open your black box classifier

Healthcare Technology Letters
A priority for machine learning in healthcare and other high stakes applications is to enable end‐users to easily interpret individual predictions. This opinion piece outlines recent developments in interpretable classifiers and methods to open black box
Paulo Jorge Gomes Lisboa
doaj   +1 more source

G-MASK Facial Adversarial Attack Combining Gaussian Filtering and MASK [PDF]

Jisuanji gongcheng
The rapid development of deep neural networks has led to significant success in fields such as computer vision and natural language processing. However, adversarial attacks may inhibit the performance of neural networks, posing a serious threat to the ...
Qian LI, Haiyun XIANG, Yuting ZHANG, Yun GAN, Haode LIAO
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source