Results 111 to 120 of about 350,421 (250)

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

The IMAP-Ultra Energetic Neutral Atom (ENA) Imager. [PDF]

Space Sci Rev
Gkioulidou M, Clark GB, Mitchell DG, Dupont AR, Anderson KL, Begley S, Bzowski M, Christian ER, Cook CE, Crew AB, Cully MJ, DeMajistre R, Diaz TJ, Drexler RJ, Dutton NT, Gingrich CJ, Hayes JR, Huber CM, Hutcheson J, Jaskulek SE, Kollmann P, LeBlanc MT, Lees J, McComas DJ, Nelson KS, Parker CW, Reisenfeld DB, Rollend EA, Schlemm CE, Schwadron NA, Verrill R, Yen J, Yin J.   +32 more
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Protocol for preparing and characterizing samples for combined microsecond freeze-hyperquenching and electron paramagnetic resonance spectroscopy. [PDF]

STAR Protoc
Wort JL, Hett T, Haardt A, Kendall O, Alaei H, Schiemann O, Kaupp UB.   +6 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Bacterial Schlafen proteins mediate phage defence. [PDF]

Nat Microbiol
Perez Taboada V, Wu Y, Cassidy R, Medvedev KE, Loeff L, Nemudraia A, Nemudryi A.   +6 more
europepmc   +1 more source

Spring 1989 [PDF]

, 1989
Valparaiso University
core   +1 more source

The Mysteries of a London Convent [transcript] [PDF]

Published in The London Miscellany and written by William Heard Hillyard (1811-1870), this 22 chapter story must have been considered a guaranteed blockbuster with the newspaper’s intended reading audience.
Hillyard, William H.
core   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Macromolecular Architecture-Directed Crystallization: Heterogeneous and Homogeneous Crystallization in Miktoarm Star Copolymers. [PDF]

Macromolecules
Chatzogiannakis D, Mygiakis E, Dulle M, Stiakakis E, Sakellariou G, Glynos E.   +5 more
europepmc   +1 more source