Results 111 to 120 of about 17,381 (237)

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Highly parallel, 1060 nm interferometric diffusing wave spectroscopy with a time-of-flight filter. [PDF]

Biomed Opt Express
Aparanji S, Zhao M, Shashidhar Nadig A, Estrada HG, Hamilton D, Srinivasan VJ.   +5 more
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Cascades of effectiveness of next-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions. [PDF]

Nat Commun
Champagne C, Lemant J, Assenga A, Kibondo UA, Lekundayo RG, Mbuba E, Moore J, Muganga JB, Ntabaliba WS, Odufuwa OG, Swai JK, Alexa M, Goers R, Golumbeanu M, Chitnis N, Ross A, N'Guessan R, Moore S, Pothin E.   +18 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

The IMAP-Ultra Energetic Neutral Atom (ENA) Imager. [PDF]

Space Sci Rev
Gkioulidou M, Clark GB, Mitchell DG, Dupont AR, Anderson KL, Begley S, Bzowski M, Christian ER, Cook CE, Crew AB, Cully MJ, DeMajistre R, Diaz TJ, Drexler RJ, Dutton NT, Gingrich CJ, Hayes JR, Huber CM, Hutcheson J, Jaskulek SE, Kollmann P, LeBlanc MT, Lees J, McComas DJ, Nelson KS, Parker CW, Reisenfeld DB, Rollend EA, Schlemm CE, Schwadron NA, Verrill R, Yen J, Yin J.   +32 more
europepmc   +1 more source

Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2

Advanced Science, EarlyView.
Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim, Wonjae Ko, Byoung‐Hoon Lee, Sanghoon Kim, Yun Do Kim, Hyunsoo Ahn, Yoon Jung, Chan Woo Lee, Kug‐Seung Lee, Eunhee Gong, Junho Lee, Minho Kim, Taeghwan Hyeon, Su‐Il In   +13 more
wiley   +1 more source

Cancer-selective photoimmunotherapy spares T cells and NK cells and promotes antitumor immunity in an allogeneic human 3D culture model. [PDF]

Photochem Photobiol
Harman RC, Lozano I, Ramos K, Quilez-Alburquerque J, Gagnon J, Cheung S, Otero N, Johnson-Shoucair A, Kercher EM, Harris JE, Rizvi I, Pilon-Thomas S, Enderling H, Hasan T, Spring BQ.   +14 more
europepmc   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Protocol for preparing and characterizing samples for combined microsecond freeze-hyperquenching and electron paramagnetic resonance spectroscopy. [PDF]

STAR Protoc
Wort JL, Hett T, Haardt A, Kendall O, Alaei H, Schiemann O, Kaupp UB.   +6 more
europepmc   +1 more source