Results 101 to 110 of about 709,620 (295)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

open access: yesAdvanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai   +15 more
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

open access: yesAdvanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu   +12 more
wiley   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

open access: yesAdvanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag   +3 more
wiley   +1 more source

Lorenzo Thomas’ Chances Are Few and the African-American Identity: Examining the Impact of Mainstream American Culture on African-American Identity [PDF]

open access: yesHyperCultura, 2014
This article examines the portrayal of African-American people in the contemporary American literature and culture. Through a close reading of a selection of Lorenzo Thomas’ poems from his collection Chances Are Few (1972), it becomes evident that ...
Sofia Politidou
doaj  

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang   +12 more
wiley   +1 more source

HIV and Black People in Canada: Protocol for a Scoping Review. [PDF]

open access: yesJMIR Res Protoc, 2023
Graham T   +6 more
europepmc   +1 more source

Group Portrait of Black Family

open access: yes
7 x 5 glass plate, four people next to wood and post fencing along a dirt road with a body of water in the background471 H86-038 Lester Black Collection Vault 418-502 Box 6 of 8 Glass plates H86-037 Lester Black Collection Wisconsin- Misc.
Black, Lester
core  

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

open access: yesAdvanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang   +32 more
wiley   +1 more source

Black People and Bodily Autonomy: Where do we go from here?

open access: yes, 2023
Through this thesis I sought to add to the literature regarding the influence of pervasive police brutality on young Black people. In it I explore the relationship between police brutality and influence on Black people’s bodily autonomy by gender, gender
NC DOCKS at East Carolina University   +1 more
core  

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