Results 131 to 140 of about 600,688 (262)

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Attitudes and beliefs regarding race-targeted genetic testing of Black people: A systematic review. [PDF]

J Genet Couns, 2023
Iltis AS, Rolf L, Yaeger L, Goodman MS, DuBois JM.   +4 more
europepmc   +1 more source

Racial trauma and its health impacts in Black people in the United States and Canada: a scoping review on conceptualizations, definitions and manifestations. [PDF]

BMC Public Health
Mudzongo FK, Robinson J, Alhassan JAK.
europepmc   +1 more source

A Systematic Review of Black People Coping With Racism: Approaches, Analysis, and Empowerment. [PDF]

Perspect Psychol Sci, 2023
Jacob G, Faber SC, Faber N, Bartlett A, Ouimet AJ, Williams MT.   +5 more
europepmc   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Construction and validity of an educational video on rapid HIV testing for young black people. [PDF]

Rev Bras Enferm
Mota NP, Galvão MTG, Félix NDC, Reis RK, Maia ICVL, Santos RLD, Maia JC, Maia JKO.   +7 more
europepmc   +1 more source

Integrative data analysis of clinical trials network studies to examine the impact of psychosocial treatments for black people who use cocaine: Study protocol. [PDF]

Contemp Clin Trials, 2023
Haeny AM, McCuistian C, Burlew AK, Ruglass LM, Espinosa A, Jordan A, Roundtree C, Lopez J, Morgan-López AA.   +8 more
europepmc   +1 more source

Selective Lithium Recovery via Photothermal Evaporation and Hydration‐Controlled Adsorption

Advanced Science, EarlyView.
A bilayer Mo‐LDH@Sponge composite is developed to couple interfacial photothermal evaporation with hydration‐controlled lithium adsorption. Solar‐induced heating dynamically regulates Li+ hydration and transport, enabling selective lithium capture from saline water. This work provides mechanistic insight into photothermal–adsorption coupling for energy‐
Yanan Pan, Yue Zhang, Guoliang Liu, Weiquan Zhan, Wencai Zhang   +4 more
wiley   +1 more source

An individual-level data synthesis of Clinical Trials Network studies to examine the impact of psychosocial treatments for Black people who use cocaine and/or opioids. [PDF]

Drug Alcohol Depend
Burlew AK, Ruglass LM, Espinosa A, McCuistian C, Haeny AM, Jordan A, Roundtree C, Lopez J, Vena A, Morgan-López AA.   +9 more
europepmc   +1 more source