Results 141 to 150 of about 16,907 (250)

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

The racial trauma task force: Clinical-community psychology approaches to healing racial trauma during COVID-19. [PDF]

Am J Community Psychol
Metzger IW, Adams SJ, Smith K, La Barrie DL, Surprenant B, Bartolomeo LA, Rea K, Nguyen J, Brown J, Brown C, Rodriguez VJ.   +10 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

An open-source closed-loop Virtual Reality system to investigate social interactions and collective behavior in fish. [PDF]

PLoS One
Sanchez S, Escobedo R, Bastien R, Lenseigne B, Denis A, Moreau M, Combe M, Straw AD, Sire C, Theraulaz G.   +9 more
europepmc   +1 more source

TRIM: Simultaneous Thermometry, Ranging, and Imaging via a Monolithic Metalens

Advanced Science, EarlyView.
ABSTRACT While metasurfaces offer a pathway beyond the discrete architectures of conventional LWIR systems, physically fusing high‐precision thermometry and passive ranging onto a single metalens remains a formidable challenge. Here, we demonstrate a monolithic, dual‐focus metalens capable of simultaneous multidimensional sensing.
Man Yuan, Yuqing Zhang, Wangzhe Zhou, Zhaojian Zhang, Xiaoyun He, Xinpeng Jiang, Yiyi Li, Xin He, Jiagui Wu, Yuanmu Yang, Junbo Yang   +10 more
wiley   +1 more source

Polydomain Liquid Crystal Elastomers with Mechanically Switchable Opacity for Thermal Shielding. [PDF]

ACS Polym Au
Turriani M, Lanfranchi A, Wiersma DS, Parmeggiani C, Lova P, Martella D.   +5 more
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Mao's Cultural War: The Origins of the Cultural Revolution Revisited. [PDF]

Mod China
Wu Y.
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Critical actions for embedding research evidence into practice: how to get the most out of your implementation scientist. [PDF]

JBI Evid Implement
Mazariego C, Gul H, Liang S, Kelly-Hanku A, Brady B, Allida S, Baffsky R, McErlean G, Crespo C, Hodgins M, Christie L, Peiris D, Debono D, MacMillan F, Ferguson C, Heneka N, Kennedy SG, Liu H, Morrow A, Fontaine G, Findlay M, Middleton S, Lim D, Straiton N, Taylor N.   +24 more
europepmc   +1 more source