Results 71 to 80 of about 819,385 (280)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Gaziantep Üniversitesi Sosyal Bilimler Dergisi, 2020 The aim of the research is to determine the economic contributions to tourism in the region of Arab tourists, which is an important value for the Eastern Black Sea Region.
Ertuğrul DÜZGÜN, Murat ÖDEMİŞ
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
BLACK SEA: A GEOPOLITICAL AND ECONOMIC PERSPECTIVE OF THE EASTERN BORDER OF THE EURO-ATLANTIC STRUCTURES [PDF]
The Black Sea is a crossing space between worlds, different cultures and global interests. Political, economic and social shifts occurred over time within the states in the area, with major consequences in the game of power and in exercising control in ...
Daniela Popa
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
, 2007 The Black Sea Trust for Regional Cooperation. Black Sea Paper Series, No. 2.
Himmelreich, Joerg, Asmus, Ronald
openaire +1 more source
Some considerations on the EU Danube Strategy and the Black Sea Region [PDF]
The Danube strategy can only constitute a step forward regarding the stated intentions, via the Black Sea Synergy program of the European Union towards the boosting of economic development, democratic governance, security etc., in the Black Sea region ...
Costel COROBAN
core
Ancient economic and social concepts in the Genoese Gasaria Region [PDF]
, 2017 The main theme of the article is the consideration of issues related to the presence of the Genoese Republic in the Northern Black Sea region in the 13th - 15th centuries.
Bocharov, Sergey G.
core
Turkey's relations and energy cooperation with the BESC
, 2019 Turkey is conducting an increasingly active energy diplomacy and in order to understand the role and strategies of Ankara in energy geopolitics, it is important to apprehend Turkey's behaviours at international level.
Yilmaz, Remziye
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source