Results 81 to 90 of about 15,619,244 (298)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

PRELIMINARY RESULTS OF GEO-ARCHAEOLOGICAL RESEARCH OBTAINED DURING THE 3rd INTERNATIONAL EXPEDITION OF THE R/V “MARE NIGRUM” (01.06.2024 – 15.06.2024)

Геологія і корисні копалини Світового океану
The research cruise was carried out within the framework of the Horizon 2020 project “Development of Optimal and Open Research Support for the Black Sea” (DOORS). The DOORS-3 program was developed as part of Work Package 4. The project started on June 1,
M.M. Ievlev, O.V. Chubenko, V.O. Iemelianov, N.O. Fedoronchuk   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Russian Geographical Studies of the Black Sea Region in 1800s - Early 1850s

RUDN Journal of Russian History
The authors in their article reveals the key areas and results of geographical research of the Black Sea region in the 1800s - early 1850s. Based on archival materials and historical and geographical research, the authors illustrate that this stage of ...
Yuri Y. Ierusalimskiy, Svetlana Y. Ierusalimskaya, Stanislav F. Amanov   +2 more
doaj   +1 more source

Geothermal sections of the earth's crust and upper mantle of the Black Sea and its northern border

Геофизический журнал, 2011
Results of measurements of heat flow and mathematical simulation of geothermic state of the lithosphere along two profiles, crossing the western and the eastern depressions of the Black Sea and flanking northward tectonic structures of different age have
R.I. Kutas
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Some considerations on the EU Danube Strategy and the Black Sea Region [PDF]

The Danube strategy can only constitute a step forward regarding the stated intentions, via the Black Sea Synergy program of the European Union towards the boosting of economic development, democratic governance, security etc., in the Black Sea region ...
Costel COROBAN
core  

DISTRIBUTED MARITIME DENIAL: DRONE WARFARE IN THE BLACK SEA AND NATO ADAPTATION IN SEMI-ENCLOSED SEAS

Studia Universitatis Babeş-Bolyai. Studia Europaea
This article examines how drone warfare in the Black Sea has reshaped the logic of maritime denial in semi-enclosed and constrained seas, and what lessons NATO should draw from Ukraine’s experience.
Raluca MOLDOVAN, Valentin NAUMESCU
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Introduction

Revista Română pentru Studii Baltice şi Nordice, 2009
I hope that the novelty of interpretation and the new findings behind the articles included in the first issue of RRSBN will attract scholarly and public interest and give birth to fresh academic debates on the exchange of cultural values between the ...
Silviu Miloiu
doaj