Results 71 to 80 of about 15,618,864 (298)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Hellenistic Period Watchtowers and Hillside Settlements Identified in “Vezirköprü” Surveys
Поволжская археологияVezirköprü, one of the largest districts of Samsun (Amisos), an important port city of the Black Sea, has been the scene of continuous settlement from the Eneolithic Period to the present day thanks to its fertile soils, rivers and its location on an ...
Temür Akın
doaj +1 more source
THE LEADERSHIP ROLE IN THE REGION - REGIONALISM - SECURITY EQUATION IN THE BLACK SEA
Bulletin of "Carol I" National Defense University, 2021 This study presents a few considerations about the leadership, the geopolitical and strategic importance of the Black Sea region, and potential threats or risks against security, stability, prosperity, and cooperation.
Mihai PANAIT
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Terry M. Black, MCRD, to his family
, 1964 Terry M. Black, writing from, MCRD, San Diego, California, to his family in Van Buren, Arkansas, in September 1964, writes about basic training and his time constraints for writing letters.
Black, Terry Moore, 1946-2022;
core +1 more source
Transfer of royal fish and the non-evolutionary history of Black Sea sturgeons
Academia BiologyThe evolutionary relationship between Caspian and Black Sea sturgeons has long attracted scholarly attention. Although the two basins have been hydrologically isolated for at least 5000 years, genetic studies reveal the presence of Black Sea ...
Gigi Tevzadze
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source