Results 71 to 80 of about 16,088,189 (206)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

First Report of Microplastic Ingestion and Bioaccumulation in Commercially Valuable European Anchovies (Engraulis encrasicolus, Linnaeus, 1758) from the Romanian Black Sea Coast

Journal of Marine Science and Engineering
Microplastics (
Andreea-Mădălina Ciucă, Elena Stoica, Lucica Barbeș   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

PRELIMINARY RESULTS OF GEO-ARCHAEOLOGICAL RESEARCH OBTAINED DURING THE 3rd INTERNATIONAL EXPEDITION OF THE R/V “MARE NIGRUM” (01.06.2024 – 15.06.2024)

Геологія і корисні копалини Світового океану
The research cruise was carried out within the framework of the Horizon 2020 project “Development of Optimal and Open Research Support for the Black Sea” (DOORS). The DOORS-3 program was developed as part of Work Package 4. The project started on June 1,
M.M. Ievlev, O.V. Chubenko, V.O. Iemelianov, N.O. Fedoronchuk   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Russian Geographical Studies of the Black Sea Region in 1800s - Early 1850s

RUDN Journal of Russian History
The authors in their article reveals the key areas and results of geographical research of the Black Sea region in the 1800s - early 1850s. Based on archival materials and historical and geographical research, the authors illustrate that this stage of ...
Yuri Y. Ierusalimskiy, Svetlana Y. Ierusalimskaya, Stanislav F. Amanov   +2 more
doaj   +1 more source

Geothermal sections of the earth's crust and upper mantle of the Black Sea and its northern border

Геофизический журнал, 2011
Results of measurements of heat flow and mathematical simulation of geothermic state of the lithosphere along two profiles, crossing the western and the eastern depressions of the Black Sea and flanking northward tectonic structures of different age have
R.I. Kutas
doaj   +1 more source

Some considerations on the EU Danube Strategy and the Black Sea Region [PDF]

The Danube strategy can only constitute a step forward regarding the stated intentions, via the Black Sea Synergy program of the European Union towards the boosting of economic development, democratic governance, security etc., in the Black Sea region ...
Costel COROBAN
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source