Results 71 to 80 of about 101,928 (268)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

PRELIMINARY RESULTS OF GEO-ARCHAEOLOGICAL RESEARCH OBTAINED DURING THE 3rd INTERNATIONAL EXPEDITION OF THE R/V “MARE NIGRUM” (01.06.2024 – 15.06.2024)

Геологія і корисні копалини Світового океану
The research cruise was carried out within the framework of the Horizon 2020 project “Development of Optimal and Open Research Support for the Black Sea” (DOORS). The DOORS-3 program was developed as part of Work Package 4. The project started on June 1,
M.M. Ievlev, O.V. Chubenko, V.O. Iemelianov, N.O. Fedoronchuk   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Russian Geographical Studies of the Black Sea Region in 1800s - Early 1850s

RUDN Journal of Russian History
The authors in their article reveals the key areas and results of geographical research of the Black Sea region in the 1800s - early 1850s. Based on archival materials and historical and geographical research, the authors illustrate that this stage of ...
Yuri Y. Ierusalimskiy, Svetlana Y. Ierusalimskaya, Stanislav F. Amanov   +2 more
doaj   +1 more source

Geothermal sections of the earth's crust and upper mantle of the Black Sea and its northern border

Геофизический журнал, 2011
Results of measurements of heat flow and mathematical simulation of geothermic state of the lithosphere along two profiles, crossing the western and the eastern depressions of the Black Sea and flanking northward tectonic structures of different age have
R.I. Kutas
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

DISTRIBUTED MARITIME DENIAL: DRONE WARFARE IN THE BLACK SEA AND NATO ADAPTATION IN SEMI-ENCLOSED SEAS

Studia Universitatis Babeş-Bolyai. Studia Europaea
This article examines how drone warfare in the Black Sea has reshaped the logic of maritime denial in semi-enclosed and constrained seas, and what lessons NATO should draw from Ukraine’s experience.
Raluca MOLDOVAN, Valentin NAUMESCU
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Introduction

Revista Română pentru Studii Baltice şi Nordice, 2009
I hope that the novelty of interpretation and the new findings behind the articles included in the first issue of RRSBN will attract scholarly and public interest and give birth to fresh academic debates on the exchange of cultural values between the ...
Silviu Miloiu
doaj