Results 131 to 140 of about 15,619,244 (298)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

A study on dynamic modeling to examine the impact of reducing water pollution on market condition in the Turkish Black Sea Basin [PDF]

The Black Sea has severe water pollution problems during the last three decades due to tremendous loads of different types of pollutants discharged from the entire basin Therefore, finding solutions to improve the environmental status of the Black Sea is
Ulger Suleyman, Higano Yoshiro
core  

Long-term hydrodynamic changes in marginal estuarine seas: the role of sea level rise and freshwater fluxes

Scientific Reports
Significant environmental changes have occurred in marginal estuarine seas in the past, driven by changes in sea level and water and salt balances. Predicting the future evolution of these seas is a scientific challenge because adequate scenario studies ...
Emil V. Stanev
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

UJAMAA Journal of The Malcolm X Insititue of Black Studies, 2 January 1972

, 1972
Preceding Publication: Malcolm X Institute of Black Studies JournalSucceeding Publication: Malcolm X Institute NewsletterPhysical Format: PeriodicalsExtent: 22 ...
Malcolm X Institute of Black Studies
core  

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Socio-Economics of the Black Sea Coast

, 2019
This chapter focused on the reviewing of socio-economic drivers (sectors directly or indirectly related to the Black Sea) as well as on the pressure on the environment, social and economic consequences of environmental changes, and riparian countries ...
Karamushka, Victor, Bon, Oleksandr
core  

Regionalization in the Black Sea Area: a Comparative Study

Romanian Journal of European Affairs, 2011
The post-Cold War period in Europe was favourable for the development of new regionalization projects which surrounded the EU. The Baltic Sea, the Mediterranean Sea and the Black Sea became the centre of new European sub-regions. Each project stands out now through a certain image that it received mirroring its type and level of regionalization emerged
openaire   +1 more source