Results 141 to 150 of about 5,485 (242)

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Objective quantification of chemotherapy-induced madarosis: a pilot study of an automated computer vision pipeline for eyebrow density assessment. [PDF]

Sci Rep
González M, Sahila A, Rodrigues A, Bernardo P, Gonzalez-Aguilera D, Barbero-García I.   +5 more
europepmc   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000-2019: a systematic analysis of health disparities. [PDF]

BMC Med
GBD US Health Disparities Collaborators, Mouhanna F, Kahn E, Schmidt CA, McHugh TA, Baumann MM, Kelly YO, La Motte-Kerr W, Cogen RM, Dai X, Gakidou E, Montalvo-Clavijo C, Li Z, Celone M, DeCleene N, Tamura K, Choi K, Camargo JT, Hinerman AS, Alvarez CS, Mensah GA, Pérez-Stable EJ, Murray CJL, Mokdad AH, Dwyer-Lindgren L.   +24 more
europepmc   +1 more source

Pulmonary arterial mechanoreceptors modulate exercise‐induced sympathetic activation in healthy humans during moderate‐intensity hypoxic exercise

The Journal of Physiology, EarlyView.
Abstract figure legend This randomized cross‐over trial (N = 12) addressed the hypothesis that selective reduction of pulmonary arterial pressure (i.e. manipulation of pulmonary arterial mechanoreceptor activation) during hypoxic exercise would reduce sympathetic outflow (muscle sympathetic nerve activity (MSNA)) in healthy humans.
Michiel T. Ewalts, Thomas D. Griffiths, Andrew J. M. Douglas, Elliott J. Jenkins, Guto Wyn Hughes, Craig D. Steinback, Lydia L. Simpson, Samuel J. Oliver, Mike Stembridge, Jonathan P. Moore   +9 more
wiley   +1 more source

Spatial temperature monitoring of preterm infants using a multi-modal camera setup. [PDF]

Med Biol Eng Comput
Voss F, Lyra S, Noehl C, Brasche M, Heimann K, Hensel L, Orlikowsky T, Leonhardt S, Lueken M.   +8 more
europepmc   +1 more source

Sound offset responses become highly informative in the auditory cortex

The Journal of Physiology, EarlyView.
Abstract figure legend Using large datasets of neural responses to diverse sounds recorded across four stages of the mouse auditory system (depicted and colour‐coded on the left), offset responses occurring after the termination of each sound (time window indicated by the orange shaded area superimposed with activity traces) were characterized and it ...
Charly Lamothe, Sophie Bagur, Etienne Gosselin, Brice Bathellier   +3 more
wiley   +1 more source

Soft Multiaxial Strain Mapping Interface with AI-Driven Decoding for Silent Speech in Noise. [PDF]

Cyborg Bionic Syst
Hong S, Yoo J, Park SM.
europepmc   +1 more source

Electrotactile frequency perception over multiple stimulation sites does not use a winner‐takes‐all mechanism

The Journal of Physiology, EarlyView.
Abstract figure legend Peripheral tactile afferents exhibit a wide range of response patterns to a pure frequency vibratory stimulus. Some afferents, including those remote from the stimulus site, fire at lower rates as they do not respond to every vibration cycle of the stimulus.
Alwin So, Hiroyuki Kajimoto, Edward N. Crawford, Richard M. Vickery, Ingvars Birznieks   +4 more
wiley   +1 more source

A Summary of Pain Locations and Neuropathic Patterns Extracted Automatically from Patient Self-Reported Sensation Drawings. [PDF]

Int J Environ Res Public Health
Bishara A, de Rinaldis E, Hue TF, Peterson T, Cummings J, Torres-Espin A, Bailey JF, Lotz JC, Reach Investigators.   +8 more
europepmc   +1 more source