Results 111 to 120 of about 2,866,338 (297)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Hybrid Energy Storage Black Start Control Strategy Based on Super Capacitor

Energies
Addressing the issue of efficient, economical, and reliable operation of a single lead-acid battery (LAB) black start system in complex scenarios, a hybrid energy storage system (HESS) black start scheme based on super capacitors (SCs) is proposed.
Dengfeng Yao, Zhezhi Chen, Yihua Zhang, Xuelin He, Yiyuan Zhang, Tengqing Xiong, Jingyuan Yin   +6 more
doaj   +1 more source

Star Clusters and Super Massive Black Holes: High Velocity Stars Production

, 2016
One possible origin of high velocity stars in the Galaxy is that they are the product of the interaction of binary systems and supermassive black holes.
Capuzzo-Dolcetta, Roberto, Fragione, Giacomo   +1 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimization Scheduling of Cold-Heat-Electricity Integrated Energy System Under Pumped Storage Gray Start

发电技术
ObjectivesPumped storage units have gray start potential. Integrating this capability with the multi-energy complementary advantages of an integrated energy system (IES) makes it suitable for system recovery under extreme events.
HOU Hui, WANG Yan, LIU Chao, ZHANG Wei, ZHOU Yangjun, LI Zhengmao, LI Zhengtian, LIN Xiangning   +7 more
doaj   +1 more source

The effect of grasses grown for seed in mixture with legumes on the incidence of weeds and soil nitrogen content [PDF]

, 2002
This report was presented at the UK Organic Research 2002 Conference on behalf of the Colloquium of Organic Researchers (COR). The incidence of weeds and the content of soil nitrogen were investigated in the first year of a field trial with organic ...
Cagas, Bohumir, Machac, Radek
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Black-start strategy of distribution network considering photovoltaic output volatility and micro-grid synergy

Diance yu yibiao
The fluctuation of photovoltaic output will cause the restored load to outage again. It is significant to exploit the dispatching resources of micro-grid to reduce load blackout loss of distribution network black-start and resist the risk of load loss ...
ZHONG Hao, FANG Chen, LI Shichun, CHEN Zitong   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source