Results 111 to 120 of about 54,509,678 (334)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Enlightenment by Any Other Name

Lateral
This essay provides a cursory sketch of the circulation of science as a fetish object in critical theory—particularly by way of an attention to the conceptual popularity of science studies and various permutations of object oriented ontologies.
Patrick Michael Teed
doaj   +1 more source

Abkhazia – 2019: from Khajimba to Khajimba

Международная аналитика, 2019
The paper considers the course and outcomes of 2019 Presidential election campaign in Abkhazia as well as factors that stipulated its character (postponement of elections because of Aslan Bzhania’s disease, the number of contenders, etc.).
V. Novikov
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Constructing Autism: Norming Thought through Mathematics, Masculinity, Whiteness and Fascism

Krisis
This paper brings together neurodiversity studies with the notion of epistemic violence to form a theoretical framework to further understand and discuss Edith Sheffer’s findings on the construction of Autism as a diagnostic concept in Nazi Vienna: the ...
Cara-Julie Kather
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The crises in the Middle East: reshaping the region’s geopolitical landscape and altering the global order

Asian Review of Political Economy
The recent events in the Middle East caught most political commentators, observers and thinkers by surprise. Who would have imagined that a non-state actor like Hamas could launch an attack on Israel and create such a complex condition for a powerful ...
Seevan Saeed
doaj   +1 more source

Poczuć czy zrozumieć bluesa? O duchowości, emocjonalności bluesa i jego społeczno-kulturowej funkcji

Annales Universitatis Paedagogicae Cracoviensis. Studia de Cultura
Muzyka bluesowa ściśle związana jest z emocjonalnością. Nie bez powodu ukuto powiedzenie: „czuć bluesa”. Od etymologii słowa, po historię powstania tego gatunku znajdujemy potwierdzenie tego związku.
Aya Al Azab-Ruszowska
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Speech is My Hammer, It\u27s Time to Build: Hip Hop, Cultural Semiosis and the Africana Intellectual Heritage [PDF]

, 2014
The article examines Hip Hop music\u27s relationship with African cultural symbolism and the discipline of Africana Studies. The author maintains that Africana Studies must reclaim the study of cultural semiosis, which may be used to contextualize Hip ...
Livingston, Samuel T.
core   +1 more source