Results 161 to 170 of about 1,131 (245)

DArTseq-Based, High-Throughput Identification of Novel Molecular Markers for the Detection of Blackleg (Leptosphaeria Spp.) Resistance in Rapeseed. [PDF]

Int J Mol Sci
Starosta E, Jamruszka T, Szwarc J, Bocianowski J, Jędryczka M, Grynia M, Niemann J.   +6 more
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Exploring Cloned Disease Resistance Gene Homologues and Resistance Gene Analogues in <i>Brassica nigra</i>, <i>Sinapis arvensis</i>, and <i>Sinapis alba</i>: Identification, Characterisation, Distribution, and Evolution. [PDF]

Genes (Basel)
Dolatabadian A, Amas JC, Thomas WJW, Sayari M, Al-Mamun HA, Edwards D, Batley J.   +6 more
europepmc   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Dual-function <i>Aspergillus sulphureoviridis</i>: antibacterial polyketides against <i>Dickeya solani</i> and elicitation of <i>Bacillus subtilis</i> lipopeptides. [PDF]

Microbiol Spectr
Wang X, Lozano-Andrade CN, Jarmusch SA, Frisvad JC, Kovács ÁT, Larsen TO.   +5 more
europepmc   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

From Recognition to Response: Resistance-Effector Gene Interactions in the Brassica napus and Leptosphaeria maculans Patho-System. [PDF]

Plants (Basel)
Qayyum Z, Thomas WJW, Amas JC, Pazos-Navarro M, Batley J.   +4 more
europepmc   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Genome-Wide Identification of <i>G3BP</i> Family in U's Triangle <i>Brassica</i> Species and Analysis of Its Expression in <i>B. napus</i>. [PDF]

Plants (Basel)
Inkabanga AT, Zhang Q, Wang S, Li Y, Chen J, Huang L, Li X, Deng Z, Yang X, Luo M, Peng L, Ren K, Chai Y, Xue Y.   +13 more
europepmc   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source