Results 121 to 130 of about 11,906 (306)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Melanopsin Stimulation Modulates Blackness Induction

A central field will become darker with increasing intensity of a surrounding annulus until it appears uniformly black. We investigated the relation between blackness induction of a central field and the stimulation of melanopsin cells in a surrounding ...
Yamakawa, Masahiko, Okajima, Katsunori, Werner, John S.   +2 more
core   +1 more source

Discriminación racial, intervención social y subjetividad.Reflexiones a partir de un estudio de caso en Bogotá

Revista de Estudios Sociales, 2007
Based on a case study in one of Bogotá's poorest neighborhoods, this article contributes to the ongoing analysis of discourses of racial discrimination in Colombia.
Mara Viveros Vigoya
doaj  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Blackness at the Intersection

Crenshaw, K., Andrews, K. and Wilson, K. (Eds.) 2024. Blackness at the Intersection. London: Bloomsbury Press.
Sonkosi, Abongile, Mxalisa, Asiphe
core   +1 more source

Cervantine Blackness [PDF]

There is no shortage of Black characters in Miguel de Cervantes’s works, yet there has been a profound silence about the Spanish author’s compelling literary construction and cultural codification of Black Africans and sub-Saharan Africa.
Jones, Nicholas R.
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Black on Black sounds

IASPM Journal
Examining literature on the under researched areas of Afrobeats and African migration to Britain, this article identifies significant internal shifts in the ethnic diversity of Black Britain —i.e., from Caribbean (predominantly Jamaican) to West African (Nigerian, Ghanaian) (ONS 2011).
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source