Results 161 to 170 of about 1,279,721 (336)
From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures
Advanced Robotics Research, EarlyView.This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...Miriam Filippiwiley +1 more sourceInteractions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy
Advanced Science, EarlyView.Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani +17 morewiley +1 more sourceYKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination
Advanced Science, EarlyView.The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian +16 morewiley +1 more sourceComprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
Cell, 2017 A. G. Robertson, Jaegil Kim, H. Al-Ahmadie, J. Bellmunt, Guangwu Guo, A. Cherniack, T. Hinoue, P. Laird, K. Hoadley, Rehan Akbani, Mauro A. A. Castro, E. Gibb, R. Kanchi, D. Gordenin, S. Shukla, F. Sánchez-Vega, D. Hansel, B. Czerniak, V. Reuter, Xiaoping Su, B. Carvalho, Vinicius S. Chagas, K. Mungall, S. Sadeghi, C. Pedamallu, Yiling Lu, L. Klimczak, Jiexin Zhang, Caleb Choo, A. Ojesina, S. Bullman, K. Leraas, T. Lichtenberg, Catherine J. Wu, N. Schultz, G. Getz, M. Meyerson, G. Mills, D. McConkey, J. Weinstein, D. Kwiatkowski, S. Lerner, Monique Albert, I. Alexopoulou, Adrian Ally, T. Antic, M. Aron, Miruna Balasundaram, J. Bartlett, S. Baylin, Allison Beaver, I. Birol, L. Boice, Moiz Bootwalla, Jay Bowen, R. Bowlby, Denise Brooks, B. Broom, W. Bshara, E. Burks, F. Cárcano, R. Carlsen, B. Carvalho, A. Carvalho, Eric P. Castle, Patrick Castro, J. Catto, David W. Chesla, E. Chuah, Sudha Chudamani, V. Cortessis, S. Cottingham, D. Crain, Erin E. Curley, S. Daneshmand, John A. Demchok, Noreen Dhalla, H. Djaladat, J. Eckman, Sophie C. Egea, J. Engel, Ina Felau, M. Ferguson, J. Gardner, J. Gastier-Foster, M. Gerken, C. Gomez-Fernandez, Jodi Harr, A. Hartmann, Lynn M. Herbert, T. Ho, R. Holt, C. Hutter, Steven J. M. Jones, M. Jordá, R. Kahnoski, K. Kasaian, Phillip H. Lai, B. Lane, Jia Liu, Laxmi Lolla, Y. Lotan, Fabiano R Lucchesi, Yussanne Ma, R. Machado, D. Maglinte, D. Mallery, M. Marra, S. Martin, Michael Mayo, A. Meraney, A. Moinzadeh, Richard A. Moore, Edna M. Mora Pinero, S. Morris, C. Morrison, A. Mungall, J. Myers, R. Naresh, P. O’Donnell, D. Parekh, J. Parfitt, J. Paulauskis, R. Penny, T. Pihl, S. Porten, Mario E. Quintero-Aguiló, N. Ramirez, W. Rathmell, K. Rieger-Christ, Charles Saller, A. Salner, G. Sandusky, C. Scapulatempo-Neto, J. Schein, A. Schuckman, N. Schultz, C. Shelton, T. Shelton, J. Simko, Parminder Singh, Payal Sipahimalani, N. Smith, H. Sofia, A. Sorcini, M. Stanton, G. Steinberg, R. Stoehr, T. Sullivan, Qiang Sun, Angela Tam, R. Tarnuzzer, Katherine Tarvin, H. Taubert, N. Thiessen, L. Thorne, Kane Tse, Kelinda Tucker, D. V. Berg, K. V. Kessel, S. Wach, Yunhu Wan, Zhining Wang, D. Weisenberger, L. Wise, Tina Wong, Ye Wu, Liming Yang, L. A. Zach, J. Zenklusen, J. Zhang, E. Zmuda, E. Zwarthoff +172 moresemanticscholar +1 more sourceMetformin Impairs Breast Cancer Growth through the Inhibition of PRMT6
Advanced Science, EarlyView.Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li +9 morewiley +1 more sourceInactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension
Advanced Science, EarlyView.Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang +17 morewiley +1 more sourceA Consensus Molecular Classification of Muscle-invasive Bladder Cancer
European Urology, 2019 A. Kamoun, A. Reyniès, Y. Allory, Y. Allory, G. Sjödahl, A. G. Robertson, R. Seiler, K. Hoadley, C. Groeneveld, C. Groeneveld, H. Al-Ahmadie, W. Choi, Mauro A. A. Castro, J. Fontugne, J. Fontugne, P. Eriksson, Qianxing Mo, Jordan Kardos, A. Zlotta, A. Hartmann, C. Dinney, J. Bellmunt, T. Powles, N. Malats, K. Chan, William Y. Kim, D. McConkey, P. Black, L. Dyrskjøt, M. Höglund, S. Lerner, F. Real, F. Radvanyi, Mattias Aine, I. Bernard‐Pierrot, B. Czerniak, E. Gibb, Jaegil Kim, D. Kwiatkowski, T. Lebret, F. Liedberg, A. Siefker-Radtke, N. Sirab, A. Taber, J. Weinstein +44 moresemanticscholar +1 more source
