Results 191 to 200 of about 1,035,047 (359)
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu+9 more
wiley +1 more source
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin+3 more
wiley +1 more source
Spontaneous rupture of the urinary bladder misdiagnosed as gastrointestinal perforation: a diagnostic pitfall in post-radiation patients. [PDF]
Kiriyama S+4 more
europepmc +1 more source
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu+11 more
wiley +1 more source
Gαi3: a crucial biomarker and therapeutic target in bladder cancer. [PDF]
Zhang L, Zhang L, Gao S, Shi X, Zuo L.
europepmc +1 more source
The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong+13 more
wiley +1 more source
Smoking-related bladder cancer burden from 1990 to 2021: An age-period-cohort analysis of the global burden of disease study. [PDF]
Yu Q+5 more
europepmc +1 more source
Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee+3 more
wiley +1 more source