Results 231 to 240 of about 1,035,047 (359)

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He   +11 more
wiley   +1 more source

CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou   +15 more
wiley   +1 more source

Late anastomotic complication after laparoscopic surgery for clinical stage I low rectal cancers located within 5 cm of the anal verge: Sub‐analysis of the ultimate trial

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Anastomotic stenosis and late fistula formation frequently emerge as secondary consequences of early AL, and represent significant complications linked to permanent stoma creation, often proving resistant to treatment. Intestinal prolapse is a characteristic anastomotic complication of ISR that can be caused by excessive intestinal mobilization.
Manabu Shimomura   +29 more
wiley   +1 more source

Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer, a study with 5-year follow-up: a plain language summary. [PDF]

open access: yesFuture Oncol
Wang B   +10 more
europepmc   +1 more source

Papillary carcinoma of the bladder in mice, obtained after peroral administration of tobacco tar [PDF]

open access: bronze, 1955
Lars R. Holsti, Pentti Ermala
openalex   +1 more source

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