Results 131 to 140 of about 331,825 (303)
Bladder CancerBackground: Many studies investigated the prognostic or predictive relevance of single nucleotide polymorphisms (SNPs) in biologically plausible genes in urinary bladder cancer (UBC) patients. Most published SNP associations have never been replicated in
Anne J. Grotenhuis +6 more
doaj +1 more source
Advanced Science, EarlyView.PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin +11 more
wiley +1 more source
Bladder Cancer Patient Advocacy: A Global Perspective
Bladder CancerOver the past 20 years, cancer patient advocacy groups have demonstrated that patient engagement in cancer care is essential to improving patient quality of life and outcomes.
Diane Zipursky Quale +8 more
doaj +1 more source
, 2017 Ursolic acid and most of its derivatives are cytotoxic to bladder cancer cells. An ursolic acid derivative. isopropyl 3 beta-hydroxyurs-12-en-28-oat (UA17), previously repotted that it exhibited potent cytotoxicity against bladder cancer cells, NTUB1 ...
Lin, Kai-Wei;Huang, A-Mei;Lin, Chi-Chen;Chang, Chia-Che;Hsu, Wei-Chi;Hour, Tzyh-Chyuan;Pu, Yeong-Shiau;Lin, Chun-Nan +1 more
core +1 more source
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Development of Systemic and Topical Drugs to Treat Non-muscle Invasive Bladder Cancer
Bladder CancerThere are few approved drugs available for the treatment of patients with non-muscle invasive bladder cancer (NMIBC) and none have been approved in the twenty-first century.
Jonathan Jarow +6 more
doaj +1 more source
Advanced Science, EarlyView.We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang +19 more
wiley +1 more source
Radical Cystectomy in the Treatment of Bladder Cancer: Oncological Outcome and Survival Predictors
, 2011 BACKGROUND/PURPOSE: To better understand the result of radical cystectomy in the treatment of bladder cancer, we analyzed our data and reported the oncological outcomes and survival predictors.
何承勳;黃昭淵;林維洲;闕士傑;蒲永孝;賴明坤;余宏政;黃國皓 +1 more
core +1 more source
Advances in Cancer Immunotherapy for Solid Tumors
Advanced Science, EarlyView.Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz +1 more
wiley +1 more source