Results 201 to 210 of about 530,197 (354)

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
wiley   +1 more source

Addressing the hidden toxicities of cancer: a call to action for clinicians, researchers and clinical trialists

BMJ Oncology
Rick Bangs
doaj   +1 more source

Bladder cancer biomarkers. [PDF]

Explor Target Antitumor Ther
Godlewski D, Bartusik-Aebisher D, Czech S, Szpara J, Aebisher D.   +4 more
europepmc   +1 more source

CLINICAL AND PATHOLOGICAL STUDIES ON RADICAL TOTAL CYSTECTOMY FOR URINARY BLADDER CANCER

, 1967
Kiichi Suzuki, Atsuo Sugita, Tadao Miura, Masakazu Kato, Yutaka Onodera, Keizi Sugawara, Teruhiko Kato   +6 more
openalex   +2 more sources

ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling

Advanced Science, EarlyView.
In this study, ferroptosis in colorectal cancer cells is induced by FK866 through the NAD⁺/STAT3/GPX4 pathway. To minimize systemic toxicity, a reactive oxygen species (ROS)‐responsive hydrogel is developed to co‐deliver FK866 and C188‐9, resulting in synergistic and localized antitumor effects.
Chenyang Ye, Mi Mi, Saimeng Shi, Lina Qi, Shanshan Weng, Lu Wang, Yier Lu, Chao Chen, Yinuo Tan, Mengyuan Yang, Cheng Guo, Rui Bai, Xuefeng Fang, Ji Wang, Ying Yuan   +14 more
wiley   +1 more source

Novel Strategies and Therapeutic Advances for Bladder Cancer. [PDF]

Cancers (Basel)
Ehrlich MI, Fox RD, Runcie KD, Stein MN, Wei AZ.   +4 more
europepmc   +1 more source

Cigarette smoking and cancer of bladder and lung. [PDF]

, 1976
Stanley Dische, Mark Saunders, M Lee, MR Bennett   +3 more
openalex   +1 more source

Bladder Cancer highlighted [PDF]

International braz j urol, 2020
openaire   +5 more sources

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Advancements in bladder cancer immunotherapy: a focus on intravesical approaches. [PDF]

Front Pharmacol
Tang X, Yu T, Tong H, Wu Y.
europepmc   +1 more source