Results 141 to 150 of about 844,682 (297)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Diabetes Increases Immunotherapy‐Related Toxicity but Not Efficacy in Metastatic Non‐Small Cell Lung Cancer: A Multicenter Retrospective Study

International Journal of Cancer, EarlyView.
ABSTRACT This multicenter retrospective study evaluated the impact of type 2 diabetes mellitus (DM) on clinical outcomes and immune‐related adverse events (irAEs) in 450 patients with metastatic non‐small cell lung cancer (NSCLC) treated with second‐line nivolumab at 17 centers between 2016 and 2024. Among these patients, 118 (26.2%) had DM.
Emre Çakır, Didem Divriklioğlu, Deniz Can Güven, Gamze Serin Özel, Oğuzhan Yıldız, Gamze Emin, Merve Keskinkılıç, Yeşim Ağyol, Onur Yazdan Balçık, Nagihan Kolkıran, Hale Gülçin Yıldırım Doğan, Pervin Can Şancı, Özge Yalıcı, Teoman Şakalar, Yurdagül Danacı, Yakup Düzköprü, Canan Yıldız, Mesut Yılmaz, İlhan Hacıbekiroğlu, Bülent Erdoğan, Saadettin Kılıçkap, Gamze Gököz Doğu, Melek Karakurt Eryılmaz, Atila Yıldırım, İlhan Öztop, İbrahim Vedat Bayoğlu, Şahnura Uzuntaş, Atike Pınar Erdoğan, Emir Çelik, Devrim Çabuk, Erdoğan Selçuk Şeber, Zehra Sadak Öcal, Hacer Demir   +32 more
wiley   +1 more source

Assessment and management of dyspareunia in peri‐ and postmenopausal women: A phenotype‐based gynecologic approach

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Dyspareunia in peri‐ and postmenopausal women is common, clinically consequential, and often undertreated in gynecologic practice. Although genitourinary syndrome of menopause (GSM) is a frequent contributor, intercourse‐related pain may also reflect vestibular, pelvic floor, dermatologic, inflammatory, treatment‐related, and psychosocial ...
Marek Broul, Marcel Vančo, Jaroslava Banýrová, Aneta Hujová   +3 more
wiley   +1 more source

Knowledge and awareness of pelvic floor dysfunction among female medical students: A multicenter cross‐sectional study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Given its high prevalence and risk for delayed recognition and management, this study compared knowledge and awareness of pelvic floor dysfunction (PFD) between first‐ and fifth‐year female medical students and examined whether knowledge translates into health‐protective behavior.
Seçilay Güneş, Yeşim Akkoç, Necmettin Yıldız, Murat Ersöz, Haydar Gök, Ayşe Karan, Belgin Erhan, Aysun Özlü, Yasemin Yumuşakhuylu, Nalan Çapan, Selcen Kanyılmaz, Elif Balevi Batur   +11 more
wiley   +1 more source

Neurogenic bladder in spinal cord injury patients

, 2015
Waleed Al Taweel, Raouf SeyamDepartment of Urology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaAbstract: Neurogenic bladder dysfunction due to spinal cord injury poses a significant threat to the well-being of patients ...
Seyam R, Al Taweel W
core  

Comparison of treatment pathways for isolated mesh associated pain syndrome (I‐MAPS) secondary to pelvic mesh devices for stress urinary incontinence (SUI)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The aim of this retrospective observational cohort study was to compare the outcome of surgical, combined and non‐surgical pathways of isolated mesh associated pain syndrome (I‐MAPS) following insertion of a single continence tape. Methods Women with a single continence tape who experienced I‐MAPS accessing the service between 2018 ...
Hawra Badri, Emily Whyley, Bharati Vyawahare, Zainab Al‐Jawahiri, Karen Ward, Richard Edmondson, Fiona Reid   +6 more
wiley   +1 more source

Levator ani muscle enthesis‐related pain in patients with bladder pain syndrome: A retrospective cross‐sectional study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Interstitial cystitis/bladder pain syndrome is a chronic pelvic pain condition with heterogenous mechanisms. Levator ani muscle (LAM) enthesis‐related pain has been proposed as a musculoskeletal contributor to bladder pain symptoms. This study investigated whether LAM enthesis‐related pain is independent of cystoscopic glomerulation ...
Hong Ci Lim, Peng‐Hui Wang, Kuan‐Cheng Lin, Hung‐Yen Chin   +3 more
wiley   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Bladder Voiding Dysfunction After Childbirth

, 2019
Tato bakalářská práce nese název "Poruchy vyprázdnění močového měchýře po porodu" a je složena ze dvou částí, a to teoretické a výzkumné. Teoretická část je především zaměřena na anatomii dolních cest močových, změny v průběhu těhotenství a po porodu ...
Suchomelová, Barbora
core   +1 more source