Results 41 to 50 of about 844,682 (297)

Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction—A Novel Hypothesis

Frontiers in Surgery, 2018
Diabetic bladder dysfunction (DBD) is a well-recognized and common symptom affecting up to 50% of all diabetic patients. DBD has a broad range of clinical presentations ranging from overactive to underactive bladder symptoms that develops in middle-aged ...
Nicole S. Klee, Cameron G. McCarthy, Steven Lewis, Jaine L. McKenzie, Jaine L. McKenzie, Julie E. Vincent, R. Clinton Webb   +6 more
doaj   +1 more source

Urodynamic characteristics of detrusor underactivity in women with voiding dysfunction.

PLoS ONE, 2018
Introduction and hypothesisVoiding dysfunction has gained interest due to its high prevalence in the elderly. This study characterized bladder dysfunction in women with voiding dysfunction using video urodynamic studies (VUDS) focused on detrusor ...
Tsai-Hwa Yang, Fei-Chi Chuang, Hann-Chorng Kuo   +2 more
doaj   +1 more source

Urinary Biomarkers Under Investigation for Overactive Bladder Syndrome

, 2015
Overactive bladder (OAB) is a symptom syndrome of urinary urgency, frequency, nocturia, and urge incontinence suggestive of lower urinary tract dysfunction.
Heit, Michael, Guirguis, Nayera
core   +1 more source

Bladder dysfunction and neuropathy in diabetes [PDF]

Diabetologia, 1976
Established urodynamic and electrophysiological techniques have been applied to assess the frequency and extent of autonomic and peripheral neuropathy in 60 subjects with diabetes mellitus; 38 were diabetics with suggestive symptoms and the others were representative newly diagnosed (11) or treated (11) diabetics. Objective evidence neuropathic bladder
A C, Buck, P I, Reed, Y K, Siddiq, G D, Chisholm, T R, Fraser   +4 more
openaire   +2 more sources

Bladder and bowel dysfunction in Down syndrome with neural tube defect: case report and review of the literature

Italian Journal of Pediatrics, 2023
Background Down syndrome is a genetic disorder caused by trisomy of chromosome 21 and characterized by an increased risk of multiorgan involvement. In Down syndrome children, functional constipation and lower urinary tract infections have been described,
Roberta Onesimo, Cristiana Agazzi, Luca Massimi, Valentina Giorgio, Chiara Leoni, Giuseppe Zampino, Claudia Rendeli   +6 more
doaj   +1 more source

Routine whole spine magnetic resonance imaging for patients with anorectal malformations

Scientific Reports
To evaluate the necessity of performing whole spine magnetic resonance imaging (MRI) as opposed to solely lumbosacral MRI for detecting high-level spinal lesions (in the brain, cervical, or thoracic spine) in patients with anorectal malformations (ARM ...
Shao-Kang Su, Hung-Chieh Chen, Chia-Man Chou, Sheng-Yang Huang, Hou-Chuan Chen   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Methylglyoxal and Advanced Glycation End Products (AGEs): Targets for the Prevention and Treatment of Diabetes-Associated Bladder Dysfunction?

Biomedicines
Methylglyoxal (MGO) is a highly reactive α-dicarbonyl compound formed endogenously from 3-carbon glycolytic intermediates. Methylglyoxal accumulated in plasma and urine of hyperglycemic and diabetic individuals acts as a potent peptide glycation molecule,
Akila Lara Oliveira, Mariana Gonçalves de Oliveira, Fabíola Zakia Mónica, Edson Antunes   +3 more
doaj   +1 more source

Bladder and sexual dysfunction following laparoscopic and open mesorectal excision for rectal cancer

Surgical Techniques Development, 2011
The objective of this review is to analyze the bladder and sexual dysfunction after laparoscopic (LTME) and open total mesorectal excision (OTME) for rectal cancer.
Muhammad Shafique Sajid, Zishan Haider, Mohammed Rafay Siddiqui, Mirza Khurrum Baig   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source