Results 41 to 50 of about 571,573 (299)

Anterior ischemic optic neuropathy following neck dissection [PDF]

, 1997
Background Ischemic optic neuropathy (ION) is a rare but devastating complication of surgery. It has traditionally been associated with intraoperative hypotension in patients with underlying arteriosclerosis. Methods We present a case of ION following
Hill, Jimmy S., Strome, Scott E., Beck, Jill, Burnstine, Michael A., Chepeha, Douglas B., Esclamado, Ramon M., MunckWikland, E, Kuylenstierna, R, Auer, G,, Lindholm, J   +9 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Modified Transurethral Incision of the Bladder Neck Treating Primary Bladder Neck Obstruction in Young Men: A Method to Improve Voiding Function and to Preserve Antegrade Ejaculation

, 2009
Objectives: To evaluate the voiding function, ejaculation status and sexual function after the novel modification of transurethral incision of the bladder neck ( TIBN) treating young men with primary bladder neck obstruction (PBNO).
YANG, STEPHEN SHEI-DEI;TSAI, YAO-CHOU;CHEN, JEN-JIH;CHEN, CHUNG-HSIN;HSIEH, JUI-HSIANG;WANG, CHUNG-CHENG, 楊緒棣;蔡曜州;陳建志;陳忠信;謝瑞香;王炯珵   +1 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Post-Radical-Prostatectomy Urinary Incontinence: The Management of Concomitant Bladder Neck Contracture

Advances in Urology, 2012
Urinary incontinence postradical prostatectomy is a common problem which adversely affects quality of life. Concomitant bladder neck contracture in the setting of postprostatectomy incontinence represents a challenging clinical problem. Postprostatectomy
Thomas King, Y. Zaki Almallah
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission

, 2018
Nitric oxide (NO) and hydrogen sulfide (H2S) play a pivotal role in nerve-mediated relaxation of the bladder outflow region. In the bladder neck, a marked phosphodiesterase type 4 (PDE4) expression has also been described and PDE4 inhibitors, as rolipram,
Barahona Gomáriz, María Victoria, Martínez Sainz, María Del Pilar, Hernández Rodríguez, Medardo Vicente, García Sacristán, Albino, Leite Fernandes, Vitor Samuel, Jiménez-Cidre; Miguel Ángel, Agis Torres, Ángel, López-Oliva Muñoz, María Elvira, Benedito Castellote, Sara, Bustamante, Salvador, Recio Visedo, María Paz, Prieto Ocejo, Dolores   +11 more
core   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

WorMa: An Undulatory Robot With Center of Mass Regulation via Internal Fluid Redistribution for Amphibious Locomotion

Advanced Robotics Research, EarlyView.
WorMa is an amphibious undulatory robot that uses Center of Mass redistribution as the sole terrain adaptation mechanism. This mechanism is based on internal fluid mass redistribution through a pump‐driven latex balloon system that creates three profiles: head‐biased, balanced, and tail‐biased.
Daniil Filimonov, Nana Obayashi
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source