Results 261 to 270 of about 445,054 (335)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Reconsidering vancomycin trough targets in critically-ill patients. [PDF]

Crit Care
Movahedan M, Lee C, Leung V.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Triplet offline causal discovery based on optimal Markov blanket and its application. [PDF]

Sci Rep
Khan W, Brekhna B, Huang J, Xie Y, Shaikh MS, Zada MSH, Zheng Y.   +6 more
europepmc   +1 more source

Efficacy of Cooling Blankets for Early Temperature Management in Heat Stroke Patients: A Multicenter Retrospective Cohort Study. [PDF]

J Multidiscip Healthc
Chen L, Jin D, Gong Z, Lu L, Zhao J, Xu S, Yang X, Zhang Y, Feng X.   +8 more
europepmc   +1 more source

Legislation on young people's social media use requires evidence-based decisions. [PDF]

EClinicalMedicine
eClinicalMedicine.
europepmc   +1 more source

Enhancing rice seedling architecture and physiology in plant factories: an integrated approach via optimized light intensity and sowing density. [PDF]

BMC Plant Biol
Mo X, Deng L, Long P, Chen G, Wang Y, Wang Y.   +5 more
europepmc   +1 more source

Methodological concerns in the feasibility study on ultrasound pelvimetry for breech birth-A tempest in a teapot. [PDF]

Acta Obstet Gynecol Scand
Lia M, Kabbani N.
europepmc   +1 more source

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The European Dual Coolant Lithium Lead breeding blanket for DEMO: status and perspectives

Nuclear Fusion, 2021
During the last years CIEMAT has been leading the activities in the European Program to develop an integral breeding blanket with advanced performances to work in a realistic DEMO scenario.
D. Rapisarda, I. Fernández-Berceruelo, A. García, J. García, B. Garcinuño, M. González, C. Moreno, I. Palermo, F. R. Urgorri, Á. Ibarra   +9 more
semanticscholar   +1 more source