Results 101 to 110 of about 201,032 (307)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Status and issues of high-temperature and high-pressure water corrosion research of fusion structural materials in Japanese DEMO reactor development

Nuclear Fusion
The activated corrosion product assessments of fusion structural materials are essential to designing components and evaluating workers’ radiation exposure.
Motoki Nakajima, Takashi Nozawa
doaj   +1 more source

Delivery of Dark Material to Vesta via Carbonaceous Chondritic Impacts

, 2012
NASA's Dawn spacecraft observations of asteroid (4) Vesta reveal a surface with the highest albedo and color variation of any asteroid we have observed so far. Terrains rich in low albedo dark material (DM) have been identified using Dawn Framing Camera (
Adams, Andreas Nathues, Andrew W. Beck, Beck, Binzel, Binzel, Bogard, Bottke, Bottke, Buchanan, Buchanan, Christopher T. Russell, Cloutis, Cloutis, Daniel D. Durda, David Blewett, David Mittlefehldt, David Nesvorny, David P. O’Brien, Debra Buczkowski, Desnoyers, Edward A. Cloutis, Elizabeth M. Palmer, Gaffey, Gaffey, Gomes, Gounelle, Grady, Harry Y. McSween, Hasegawa, Hiroi, Holger Sierks, Holsapple, Jaumann, Jean-Philippe Combe, Jennifer E.C. Scully, Jian-Yang Li, Jutzi, Keil, Kris J. Becker, Le Corre, Levison, Love, Love, Lucille Le Corre, Mayne, Megha U. Bhatt, Melosh, Michael J. Gaffey, Mittlefehldt, Nesvorny, Nesvorny´, O’Brien, Paul J. Mann, Reddy, Reddy, Rivkin, Robert Gaskell, Rubin, Sierks, Svetsov, Taylor, Thomas, Thomas B. McCord, Tsiganis, Vishnu Reddy, Wasson, William F. Bottke, Wilson, Wilson, Wilson, Zolensky   +71 more
core   +1 more source

(Invited) towards a vertical and damage free post-etch InGaAs fin profile: dry etch processing, sidewall damage assessment and mitigation options [PDF]

, 2015
Based on current projections, III-Vs are expected to replace Si as the n-channel solution in FinFETs at the 7nm technology node. The realisation of III-V FinFETs entails top-down fabrication via dry etch techniques. Vertical fins in conjunction with high
Droopad, Ravi, Fu, Yen-Chun, Golding, Terry G, Hossain, Khalid, Hurley, Paul K, Ignatova, Olesya, Jain, Manish, Li, Xu, Millar, David A J, Peralagu, Uthayasankaran, Povey, Ian, Steer, Matthew, Thayne, Iain   +12 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Experimental and Numerical Studies of Window Shutters Under Bushfire Radiant Heat Exposure

Fire
The growing intensity and frequency of bushfires across the globe pose serious threats to building safety when it comes to the vulnerability of glass windows. During bushfires, extreme heat can cause significant damage to these windows, creating openings
Birunthan Perinpalingam, Anthony Ariyanayagam, Mahen Mahendran   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Toughened Thermal Blanket for MMOD Protection [PDF]

Thermal blankets are used extensively on spacecraft to provide passive thermal control of spacecraft hardware from thermal extremes encountered in space.
Christiansen, Eric L., Lear, Dana M.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Nuclear Non-Proliferation Treaty\u27s Obligation to Transfer Peaceful Nuclear Energy Technology: One Proposal of a Technology [PDF]

, 1995
This Essay discusses the technology transfer provisions of the Treaty on the Non-Proliferation of Nuclear Weapons (“NPT”) and describes the Radkowsky Thorium Reactor, which is being developed as a peaceful nuclear energy ...
Grae, Seth
core   +1 more source