Results 131 to 140 of about 200,079 (309)
Focus on plasma-facing materials in nuclear fusion reactors
Materials Research ExpressFusion energy is a promising, safe, and reliable green energy solution to the increasing energy demand. However, there are several materials challenges that need to be overcome to increase the technical readiness to a level that enables a fusion pilot ...
Dwaipayan Dasgupta +5 more
doaj +1 more source
He huaxue yu fangshe huaxueHelium-Cooled Ceramic Breeding Blanket Module(HCCB-TBM) will be installed on ITER machine to test its tritium breeding performance and thermal removal ability.
WANG Jun +4 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Use of facia lata graft blanket wrap to prevent fistulas in hypospadias repair
Journal of Indian Association of Pediatric Surgeons, 2006 OBJECTIVES: To evaluate the efficacy of fascia lata graft in hypospadias repair, especially in cases with paucity of subcutaneous dartos pedicle or tunica vaginalis flap, with the aim to avoid the potential complication of urethrocutaneous fistula and ...
Gupta Vipul, Sharma Shyam
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Soft X-Ray Exposure Testing of FEP Teflon for the Hubble Space Telescope [PDF]
The FEP Teflon (DuPont) multilayer insulation (MLI) thermal-control blanket material on the Hubble Space Telescope is degrading in the space environment.
deGroh, Kim K.
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source