Results 21 to 30 of about 9,436 (234)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Politiche sulla scienza aperta in Italia: solo "bla bla bla"

, 2021
Mentre l UNESCO si accinge ad adottare la raccomandazione sull Open Science, la Francia ha da poco varato il secondo piano nazionale sulla scienza aperta, e l UE non solo finalizza il progetto Horizon Europe all apertura dei risultati della ricerca ma inserisce le pratiche dell Open Science tra gli elementi di valutazione delle proposte ...
openaire   +2 more sources

Bla‐bla‐bla: video chat service on the Internet – a market feasibility study [PDF]

Qualitative Market Research: An International Journal, 2004
The Internet is changing the way that companies carry out their business and, in fact, constitutes an entirely new application domain, which makes product innovation possible. Moreover, it is a new medium for reaching consumers, which is a central preoccupation to organisations in the current business market. Here interest lies in video chatting on the
Lindgreen, Adam, Antioco, Michael, Wetzels, Martin   +2 more
openaire   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Seguridad en Entornos de Educación Virtual

Memoria Investigaciones en Ingeniería, 2016
En los últimos tiempos se han estado incorporando diferentes tecnologías de información y comunicaciones (TICs) a los ámbitos de educación virtual, hasta el punto de convertirse en herramientas esenciales para el apoyo de los procesos de enseñanza y ...
Hernán Santiso, Juan Matias Koller, Mauricio Gabriel Bisaro   +2 more
doaj  

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

CÓMPUTO DE ALTO DESEMPEÑO PARA OPERACIONES VECTORIALES EN BLAS-1 // INCREASED COMPUTATIONAL PERFORMANCE FOR VECTOR OPERATIONS ON BLAS-1

Publicaciones en Ciencias y Tecnología, 2014
The functions library, called Basic Linear Algebra Subprograms (BLAS-1), is considered the programming standard in scientific computing. In this work, we focus on the analysis of various code optimization techniques to increase the computational ...
José Antonio Muñoz Gómez, Abimael Jiménez Pérez, Gustavo Rodríguez Gómez   +2 more
doaj  

Hydrogen bonding patterns and cooperativity in polyproline II helical bundles

Communications Chemistry
Hydrogen bond cooperativity (HBC) plays an important role in stabilizing protein assemblies built by α-helices and β-sheets, the most common secondary structures.
Rubén López-Sánchez, Douglas V. Laurents, Miguel Mompeán   +2 more
doaj   +1 more source

Unidad de lo psíquico y lo físico. Expresión de un principio en la Educación Física universitaria

Ciencia y Educación, 2022
Las generalidades y particularidades del proceso pedagógico que tienen lugar en el contexto universitario se fundamentan por lo general, en regularidades y principios pedagógicos de la teoría de la educación y de la enseñanza y, en lo particular, en los
Arturo Ignacio Navas López, Roberto Inocencio Chávez Chávez, Yaquelmi Benitez Reyes, Juan Miguel Peña Fernández   +3 more
doaj  

PENGARUH FUNGISIDA BERBAHAN AKTIF ASAM KLORO BROMO ISOSIANURIK TERHADAP INTENSITAS PENYAKIT BLAS, HAWAR PELEPAH DAUN DAN BERCAK DAUN CERCOSPORA PADA TANAMAN PADI DI GADINGREJO, PRINGSEWU

Jurnal Agrotek Tropika, 2014
Padi (Oryza sativa L.) merupakan tanaman penghasil beras yang menjadi makanan pokok bagi hampir seluruh penduduk di Indonesia. Salah satu kendala dalam budidaya padi adalah karena serangan berbagai macam cendawan, diantaranya cendawan Pyricularia oryzae
Pendi Setiawan, Titik Nur Aeny, Efri Efri   +2 more
doaj   +1 more source