Results 41 to 50 of about 80,415 (249)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Radiation-induced variation in blast disease resistance in rice

Japanese Journal of Breeding, 1960
A rice variety widely grown in Taiwan, Taichung No. 65, belonging to the “Horai” or Japonica type and suseptible to the blast desease(caused by Piricularia oryzae), was used for this irradiation experiment. The kinds and dosages of radiation used were gamma-ray (form Co60 source, 11 Kr), X-ray (20Kr and 25Kr), and thermal neutron (15hrs.
LIN, KEH-MING, LIN, PAO-CHIN
openaire   +2 more sources

Synchronised regulation of disease resistance in primed finger millet plants against the blast disease

Biotechnology Reports, 2020
Plants, being sessile, are exposed to an array of abiotic and biotic stresses. To adapt towards the changing environments, plants have evolved mechanisms that help in perceiving stress signals wherein phytohormones play a critical role. They have the ability to network enabling them to mediate defense responses. These endogenous signals, functioning at
Savita Veeranagouda Patil, Belur Satyan Kumudini, Hosur Gnanaprakash Pushpalatha, Savitha De Britto, Shin-ichi Ito, Surya Sudheer, D.P. Singh, Vijai Kumar Gupta, Sudisha Jogaiah   +8 more
openaire   +3 more sources

Genome-Wide Association of Rice Blast Disease Resistance and Yield-Related Components of Rice

Molecular Plant-Microbe Interactions, 2015
Robust disease resistance may require an expenditure of energy that may limit crop yield potential. In the present study, a subset of a United States Department of Agriculture rice core collection consisting of 151 accessions was selected using a major ...
Xueyan Wang, Melissa H. Jia, Pooja Ghai, Fleet N. Lee, Yulin Jia   +4 more
doaj   +1 more source

Genome wide association studies for japonica rice resistance to blast in field and controlled conditions

Rice, 2020
Background Rice blast, caused by the fungus Pyricularia oryzae, represents the most damaging fungal disease of rice worldwide. Utilization of rice resistant cultivars represents a practical way to control the disease.
Andrea Volante, Alessandro Tondelli, Francesca Desiderio, Pamela Abbruscato, Barbara Menin, Chiara Biselli, Laura Casella, Namrata Singh, Susan R. McCouch, Didier Tharreau, Elisa Zampieri, Luigi Cattivelli, Giampiero Valè   +12 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Analysis of Blast Disease Resistance Induced by Probenazole in Rice

Journal of Pesticide Science, 1994
いもち病抵抗性誘導剤であるプロベナゾールを処理したイネでは細胞核遺伝子のうち特定のものが活性化されること, この状態のイネにいもち病菌を感染させると光合成関連遺伝子の活性が低下することを見いだした. プロベナゾール処理によって活性化される遺伝子のうちの一つを単離した. この遺伝子は緑葉, 茎など緑色部分でのみ発現し, 根では発現していなかった. このことからプロベナゾールの作用は細胞分化, 特に緑化と密接に関連していることが示唆された.
MINAMI, Eiichi, ANDO, Ikuo
openaire   +2 more sources

Panicle blast 1 (Pb1) resistance is dependent on at least four QTLs in the rice genome

Rice, 2017
Background Rice blast is the most serious disease afflicting rice and there is an urgent need for the use of disease resistance (R) genes in blast tolerance breeding programs.
Haruhiko Inoue, Mitsuru Nakamura, Tatsumi Mizubayashi, Akira Takahashi, Shoji Sugano, Shuuichi Fukuoka, Nagao Hayashi   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Keparahan Penyakit Blas Pyricularia oryzae dan Analisis Gen Virulensi Menggunakan Metode Sequence Characterized Amplified Region

Jurnal Fitopatologi Indonesia, 2021
Severity of Blast Disease and Analysis of Virulence Gene Using Sequence Characterized Amplified Region Method Rice blast disease caused by the fungus Pyricularia oryzae (teleomorph: Magnaporthe oryzae) is one of the important diseases in rice ...
Gilang Kurrata, Tutik Kuswinanti, Andi Nasruddin   +2 more
doaj   +1 more source