Results 191 to 200 of about 47,434 (257)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Cleaning products and classes associated with poor respiratory health. [PDF]

Environ Sci Pollut Res Int
Dai X, Abramson MJ, Hamilton GS, Thompson BR, Svanes C, Benke G, Kaushik S, Dharmage SC, Lodge CJ.   +8 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Functional OCT with parfocal retinal stimulation enables multi-site optoretinography under a single dark adaptation. [PDF]

Biomed Opt Express
Sadhin AH, Son T, Ahmed S, Ma G, Sadhin MA, Yao X.   +5 more
europepmc   +1 more source

Green and Scalable Synthesis of Efficient and Stable CsPbBr3 Perovskite Quantum Dots Enables Low‐Threshold Amplified Spontaneous Emission

Advanced Science, EarlyView.
Green and scalable synthesis of CsPbBr3 perovskite quantum dots using bio‐sourced lecithin and hexane enables single‐batch production over 10 grams. Suppressed Auger recombination and electron‐phonon coupling yields 95% PLQY, enhanced stability, and low ASE thresholds of 230.4 (ns) and 50.1 (fs) µJ cm−2 in neat films. ABSTRACT Halide perovskite quantum
Yongfeng Liu, Mengting Zhang, Qingyu Xie, Kehao Hu, Bowen Zhang, Zhe Zhang, Jie Yang, Zhiping Hu, Juan Du, Jia Wang, Min Zhou   +10 more
wiley   +1 more source

Identification and removal of contamination in palaeoproteomic analysis of dental enamel. [PDF]

Sci Rep
Fagernäs Z, Sieling S, Troché G, Bakker JK, Olsen JV, Welker F.   +5 more
europepmc   +1 more source

Gas Sensing With Aerogels: A Critical Review on Structure‐Property Correlations and Performance Optimization

Advanced Science, EarlyView.
With high specific surface area, and adjustable interface, aerogel provides a multi‐functional platform for gas sensing. This review systematically links structural parameters (specific surface area, pore size, heterojunctions) to sensing metrics (sensitivity, selectivity, stability), critically evaluates optimization strategies, and outlines future ...
Hao Guo, Linheng He, Qinxin Wang, Man Yuan, Shoutian Qiu, Wei Liu, Sheng Cui   +6 more
wiley   +1 more source

Effect of masking and bleach-shade composite resins on the color and translucency of composite restorations: an in vitro study. [PDF]

BMC Oral Health
Kandemir Ülker E, Erenel AO, Delikan E, Bağ İ, Çalişkan S.   +4 more
europepmc   +1 more source

Formation of Light‐Emitting Defects in Ag‐Based Memristors

Advanced Electronic Materials, EarlyView.
How does a memristor begin to emit light‐before it even conducts? This work reveals that nanoscale silver clusters form, diffuse, and aggregate during activation, driving early photoluminescence ahead of current flow. Linking these precursor dynamics to later electroluminescence, it uncovers the origins of light emission and enables precise control of ...
Diana Singh, Maciej Ćwierzona, Régis Parvaud, Sebastian Maćkowski, Alexandre Bouhelier   +4 more
wiley   +1 more source

Radial Profile-Based Quantification of Centrosomal Proteins. [PDF]

Bio Protoc
Wainman A.
europepmc   +1 more source