Results 131 to 140 of about 67,557 (234)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen   +7 more
wiley   +1 more source

Near‐Infrared Cocrystal Nanofluorophore with Enhanced Two‐Photon Absorption Cross Sections

open access: yesAdvanced Science, EarlyView.
In this study, organic cocrystal nanoparticles (BP4TC‐NPs) were prepared via a nanoprecipitation method using an amphiphilic surfactant. The resulting cocrystal nanoparticles exhibit exceptional nonlinear optical properties and bioimaging capabilities.
Liangmeng Hao   +8 more
wiley   +1 more source

Multi‐Force‐Driven Self‐Recoverable SWIR Mechanoluminescence for Underwater Communication

open access: yesAdvanced Science, EarlyView.
This study represents the first demonstration of self‐recoverable mechanoluminescent (ML) within a single material across diverse mechanical modes, enabled by the synergistic coupling of piezoelectric and triboelectric effects. Through a combinatorial doping approach, the MgNb2O6 crystal exhibits breakthrough short‐wavelength infrared ML performance ...
Jie Sun   +13 more
wiley   +1 more source

The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models

open access: yesAdvanced Science, EarlyView.
Direct‐current produces nerve lesioning through discrete electrochemical reactions. Using hypoxia‐sensitive locust nerves and hypoxia‐tolerant leech nerves, we map three injury pathways: cathodic oxygen reduction, cathodic alkalization, and anodic chloride oxidation. These findings establish electrochemical lesioning—the “Faraday Scalpel”—as a precise,
Petra Ondráčková   +5 more
wiley   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

open access: yesAdvanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin   +15 more
wiley   +1 more source

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