Results 81 to 90 of about 52,618 (383)
WASP family proteins and formins compete in pseudopod- and bleb-based migration
Journal of Cell Biology, 2018 Actin pseudopods induced by SCAR/WAVE drive normal migration and chemotaxis in eukaryotic cells. Cells can also migrate using blebs, in which the edge is driven forward by hydrostatic pressure instead of actin.
Andrew J. Davidson +3 more
semanticscholar +1 more source
Bleb Nucleation through Membrane Peeling. [PDF]
Physical Review Letters, 2016 We study the nucleation of blebs, i.e., protrusions arising from a local detachment of the membrane from the cortex of a cell. Based on a simple model of elastic linkers with force-dependent kinetics, we show that bleb nucleation is governed by membrane ...
Ricard Alert, J. Casademunt
semanticscholar +1 more source
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen +16 more
wiley +1 more source
Case Reports in Ophthalmology, 2014 Purpose: To report a case of autologous transplantation of a free Tenon's graft to repair excessive bleb leakage after trabeculectomy. Case Report: A 39-year-old Japanese woman presented with severe hypotony in her left eye.
Motofumi Kawai +4 more
doaj +1 more source
Actomyosin-based Self-organization of cell internalization during C. elegans gastrulation [PDF]
, 2012 Background: Gastrulation is a key transition in embryogenesis; it requires self-organized cellular coordination, which has to be both robust to allow efficient development and plastic to provide adaptability. Despite the conservation of gastrulation as a
Bao, Zhirong +4 more
core +2 more sources
Annals of Neurology, EarlyView.Objective Aneurysm wall enhancement (AWE) may predict aneurysm growth and rupture in the short‐term, but there is a lack of long‐term follow‐up studies. We aimed to determine whether unruptured intracranial aneurysms (UIAs) with AWE have a higher probability of aneurysm instability during long‐term follow‐up compared with those without AWE. Methods For
Laura T. van der Kamp +9 more
wiley +1 more source
The septin cytoskeleton facilitates membrane retraction during motility and blebbing. [PDF]
, 2012 Increasing evidence supports a critical role for the septin cytoskeleton at the plasma membrane during physiological processes including motility, formation of dendritic spines or cilia, and phagocytosis.
Chen, Yi-Chun M +3 more
core
A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration [PDF]
, 2014 Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness.
Asuri, Prashanth +2 more
core +3 more sources
Image based modeling of bleb site selection
Scientific Reports, 2017 Cells often employ fast, pressure-driven blebs to move through tissues or against mechanical resistance, but how bleb sites are selected and directed to the cell front remains an open question.
Sharon Collier +3 more
semanticscholar +1 more source
The Anatomical Record, EarlyView.Abstract The three mammalian auditory ossicles enhance sound transmission from the tympanic membrane to the inner ear. The anterior anchoring of the malleus is one of the key characters for functional classification of the auditory ossicles. Previous studies revealed a medial outgrowth of the mallear anterior process, the processus internus ...
Franziska Fritzsche +2 more
wiley +1 more source