Results 41 to 50 of about 985,177 (184)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Bleb geometry.

, 2013
Cross-sectional Ocular Coherence Tomography image left eye of a simple bleb morphology, functioning bleb of IOP 10 (“Visante OCT” Zeiss HE 10/1/37 RVEEH – image date 8/4/08). Note this does not imply that this bleb size or shape is optimal.
David W. Smith (183635), Michael Coote (361170), Jonathan G. Crowston (216498), Bruce S. Gardiner (183615)   +3 more
core   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Analysis of bleb morphology after trabeculectomy with Visante anterior segment optical coherence tomography

, 2006
Background: To describe the use of anterior segment optical coherence tomography (OCT) in imaging intrableb morphology after trabeculectomy. Methods: 14 post-trabeculectomy eyes from 11 primary open angle glaucoma and 3 primary angle closure glaucoma ...
C. K.-s. Leung, Kwong, Yolanda Yuen Ying, Mohamed, Shaheeda, F. C.-h. Li, Leung, Dexter Yu Lung, D. Y.-l. Leung, Li, Felix Chi Hong, Y. Y.-y. Kwong, Chung-Chai, Chi, Yick, Doris Wai Fong, C. Chung-chai, Tham, Clement Chee Yung, Leung, Christopher Kai Shun, Lam, Dennis Shun Chiu, D. W.-f. Yick, S. Mohamed, D. S.-C. Lam, C. C.-y. Tham   +17 more
core   +1 more source

Case series of subconjunctival Inj mitomycin C with bleb massage in postoperative period of mitomycin C augmented trabeculectomies for bleb modulation

Indian Journal of Ophthalmology. Case Reports
We report four cases of use of Inj mitomycin C (MMC) (20 mcg) in the subconjunctival space adjacent to bleb of MMC augmented trabeculectomies, followed by bleb massage regimen.
Anukool S Deshpande, Sushama N Rahate
doaj   +1 more source

Recurrence of gigantic overhanging bleb post excision: a case report

, 2023
Purpose: To report the case of an extremely large overhanging bleb, extending from superior fornix to limbus, in a 57-year-old poorly controlled diabetic, six years after trabeculectomy for an uncontrollrimary open angle glaucoma (POAG) with recurrence ...
Gotmare, Nikhil, Saran, Ravinder, Gotmare, N, Aggarwal, Himshikha, Singh, Kirti, Jain, Pragya, Bhattacharyya, Mainak, Aggarwal, H, Bhattacharyya, M, Saran, R, Jain, P, Singh, K   +11 more
core   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Are there morpho‐acoustic patterns of adaptation in nonhuman primate ears? Testing the role of ecology and habitat in shaping ear morphology and function

The Anatomical Record, EarlyView.
Abstract Analysis of the variation in the bony structures of the inner and middle ear provides critical insights into functional morphology, as well as adaptive morphology across primates. In this study, we investigated whether ear morphology patterns are related to the ecological characteristics of species and their habitats to test two acoustic ...
Myriam Marsot, Rémi Laffont, Émilie Steimetz, Patricia Balaresque, Sébastien Couette   +4 more
wiley   +1 more source

Oldest well‐preserved euprimate petrosal, from the early Eocene of India (Vastan Lignite Mine, Gujarat)

The Anatomical Record, EarlyView.
Abstract An exquisitely preserved, isolated partial petrosal with associated fragmentary stapes is described from the Vastan Lignite Mine (Gujarat, India), dated to the early Eocene (~54.5 Ma). Several anatomical traits (e.g., large petrosal plate; posterolateral entry of the internal carotid artery to the tympanic cavity; bony tubes surrounding the ...
Mary T. Silcox, Kenneth D. Rose, Rachel H. Dunn, Kishor Kumar, Rajendra S. Rana, Ashok Sahni, Lachham Singh, Thierry Smith, Jordan W. Crowell   +8 more
wiley   +1 more source

Different shape but the same topographical complexity—The lingual gross anatomy of the Saimaa (Pusa saimensis) and Baltic ringed seals (Pusa hispida botnica)

The Anatomical Record, EarlyView.
Abstract Despite the distinctly different shapes of their tongues, the tongue gross anatomy of Saimaa ringed seal closely resembled that of Baltic ringed seal. There were no differences in the extrinsic and intrinsic tongue muscles or their associated vascularization and innervation between Saimaa and Baltic ringed seals.
Juha Laakkonen, Heini Nihtilä
wiley   +1 more source