Results 31 to 40 of about 1,666,748 (304)

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Impaired platelet function in Hermansky-Pudlak syndrome associated with novel mutations in HPS3, HPS6 and HPS8 genes

Bleeding, Thrombosis and Vascular Biology
We report three unrelated cases of Hermansky-Pudlak (HP) characterized by novel mutations in HPS3 (compound heterozygosity for c.1457G>A and c.1813G>T), HPS6 (homozygous c.210_211insGGGCC), and HPS8 (homozygous c.299dupC in BLOC1S3) genes.
Lisa Pieri, Silvia Linari, Francesca Salvianti, Monica Attanasio, Giancarlo Castaman   +4 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Pharmacist-Managed Hydroxyurea Prescribing Protocol Improves Uptake and Optimization among Patients with Sickle Cell Disease

Advances in Hematology
Sickle cell disease (SCD) is a common genetic disorder with potentially serious sequelae that can be effectively treated with hydroxyurea. Despite its favorable benefit-risk profile, hydroxyurea uptake in patients with SCD is low.
Cameron Roessner, Trudy Sale, Kelsey Uminski, Dawn Goodyear, Natalia Rydz   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: research priorities for mucocutaneous bleeding disorders [PDF]

, 2023
Excessive or abnormal mucocutaneous bleeding (MCB) may impact all aspects of the physical and psychosocial wellbeing of those who live with it (PWMCB).
Kouides, Peter A, Neeves, Keith, Barbara A. Konkle, Peter A. Kouides, Joyner, Lora C, Julie Jaffray (14797045), G Shellye Horowitz (14797039), Christi Humphrey, Lora C. Joyner, Kasthuri, Raj, Robert Montgomery (3441428), Julie Jaffray, Scappe, Nikole, Trapane, Pamela, Tickle, Kelly, Tarango, Cristina, Waters, Brittany, Pamela Trapane (14797060), Paulette C. Bryant (14797033), Raj Kasthuri (14797051), Hale, Sarah, Montgomery, Robert, Brittany Waters, Cristina Tarango, Robert F. Sidonio, Jr (14797030), Nikole Scappe (10685464), Meadow Heiman, Heiman, Meadow, G Shellye Horowitz, Jaffray, Julie, Konkle, Barbara A, Christi Humphrey (14797042), Nikole Scappe, Michael Wang (265591), Peter A. Kouides (14797054), Randi, Anna M, Keith Neeves, Michael Wang, Sidonio, Robert F, Kelly Tickle, Di Paola, Jorge, Flood, Veronica H, Horowitz, G Shellye, Barbara A. Konkle (8882348), Kelly Tickle (14797057), Sarah Hale (4181422), Paulette C. Bryant, Anna M. Randi, Veronica H. Flood (14797066), Bryant, Paulette C, Robert F. Sidonio, Jr, Brittany Waters (14797063), Pamela Trapane, Raj Kasthuri, Veronica H. Flood, Humphrey, Christi, Jorge Di Paola, Lora C. Joyner (14797048), Anna M. Randi (7444532), Wang, Michael, Robert Montgomery, Cristina Tarango (3146682), Jorge Di Paola (3181545), Keith Neeves (11189471), Sarah Hale, Meadow Heiman (14797036)   +65 more
core   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

DRAWBACKS OF PERSONALIZATION OF PROPHYLAXIS AMONG ADULT MEN WITH HEMOPHILIA A

Hematology, Transfusion and Cell Therapy, 2021
Personalization of prophylaxis applying population pharmacokinetic (PK) tools has recently rendered fewer bleeding episodes for people with hemophilia A (PwHA).
PC Giacometto, L Hirle, J Alvares-Teodoro, LL Jardim, RM Camelo   +4 more
doaj   +1 more source