Results 141 to 150 of about 54,705 (323)

Influence of Placenta Extract Intake on Periodontal Diseases and Oral Environment: A Case Series

open access: yesInternational Medical Case Reports Journal
Hizuru Miyamoto,1 Kentarou Tahara,2 Eiichi Hirano2 1Dentistry and Oral Surgery of Happy Town, Shiki, Saitama, Japan; 2Medical Affairs Department, Japan Bio Products, Co., Ltd., Shibuya, Tokyo, JapanCorrespondence: Eiichi Hirano, Medical Affairs ...
Miyamoto H, Tahara K, Hirano E
doaj  

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

open access: yesAdvanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang   +9 more
wiley   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

open access: yesAdvanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang   +16 more
wiley   +1 more source

Prevalence of Plaque Induced Gingivitis Among Dental Students in College of Dentistry, Hawler Medical University.

open access: yesErbil Dental Journal
Background and objective: Gingival inflammation in response to bacterial plaque accumulation is considered the key risk factor for the onset of periodontitis.
Zainab Salim Mahmood   +2 more
doaj  

Atherogenic Biomarkers and Gingival Bleeding Among Smokers

open access: yesKardiyovasküler Tıp E Dergisi/E Journal of Cardiovascular Medicine
Objectives: Smoking is a significant risk factor for gingivitis and has detrimental effects on both oral health and the cardiovascular system. This study aimed to evaluate the association between cardiovascular biomarkers and gingival bleeding among ...
Swati Mittal   +13 more
doaj   +1 more source

Exploring content and psychometric validity of newly developed assessment tools for itch and skin pain in atopic dermatitis. [PDF]

open access: yes, 2019
BackgroundAtopic dermatitis (AD) is a common skin disorder characterized by chronic inflammation, altered skin barrier function, and inflammatory cell skin infiltration that decreases health-related quality of life (HRQoL).
Abetz-Webb, Linda   +11 more
core  

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

open access: yesAdvanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai   +13 more
wiley   +1 more source

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