Results 141 to 150 of about 20,192 (238)

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

Advanced Science, EarlyView.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen, Boqiang Liu, Jing He, Weijun Zhao, Weiqi Li, Lingfeng Ma, Lidan Hou, Yi Wang, Chenqi Jin, Yushun Chang, Jie Lin, Jia Zhao, Binghan Jin, Yuanshi Tian, Xiujun Cai, Liang Shi, Yifan Wang   +16 more
wiley   +1 more source

Upper GI bleeding caused by transesophageal echocardiography probe after cardiac valve surgery

, 2016
Robert Chen
openalex   +1 more source

The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice

Advanced Science, EarlyView.
Piezo1 upregulates in cartilage callus during bone repair, where its deletion impairs ossification and healing in mice, while activation enhances these processes. Sirt1 positively regulates Piezo1 expression and activity to promote osteogenesis and bone repair in mice.
Donghao Gan, Yi Ran, Hong Pan, Qinnan Yan, Wenjing Zhang, Bo Zhou, Pengzhi Xu, Rongdong Liao, Haipeng Xue, Will Jiang, Tailin He, Qingyun Jia, Lei Qin, Francis Y Lee, Di Chen, Chuanju Liu, Guozhi Xiao   +16 more
wiley   +1 more source

T1WI‐SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease

Advanced Science, EarlyView.
We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li, Aijun Shen, Xiaolong Gao, Chao Lin, Zongliang Huang, Qi Lv, Junjun Tang, Xiaolong Ma, Jiong Ni, Ju Tian, Jiaqi Wu, Xiaowen Xu, Wei Wang, Peijun Wang   +13 more
wiley   +1 more source

A Programmable, 3D Neuron‐On‐Chip Platform Integrating Near Real‐Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling

Advanced Science, EarlyView.
A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani, Kar Wey Yong, Mawafag F. Alhasadi, Amir Hamedzadeh, Leila Shahsavari, Atefeh Rafiei, Kalvin Wu, Omakhowa Agbojo, Anupriya Singh, Kunal Karan, Salvatore Federico, Arindom Sen, Amir Sanati‐Nezhad   +12 more
wiley   +1 more source

Heat Probe Method as Endoscopic Hemostatsis for Upper Gastrointestinal Bleeding

, 1986
Mitsuhiro Tada
openalex   +2 more sources

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

Advanced Science, EarlyView.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu, Guigen Zhang, Yuan Lin, Shiming Yi, Jingyu Yang, Xueying Lin, Deli Song, Zhiheng Liu, Jiayu Zhang, Ying Zeng, Shanyu Huang, Zhen Fan, Jifu Zhang, Ying Liu, Cheng Hu, Wenbo Zhu, Wei Yin, Jun Hu, Guangmei Yan, Jing Cai, Jiankai Liang   +20 more
wiley   +1 more source

The Effect of Debridement for Bleeding Periodontal Pockets on Probing During Maintenance Care.

, 1992
Takeshi SUEDA, Makoto Takeuchi, Mutsumi Minami, Makoto Yokota   +3 more
openalex   +2 more sources

A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

Advanced Science, EarlyView.
A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri, Adam Nyul‐Toth, Madison Milan, Eva Troyano‐Rodriguez, Sherwin Tavakol, Jennifer Ihuoma, Zeke Reyff, Rakesh Rudraboina, Rafal Gulej, Raymond Jang, Anna Csiszar, Zoltan Ungvari, Audrey Cleuren, David R Miller, Andriy Yabluchanskiy, Mickael Tanter, Stefano Tarantini   +16 more
wiley   +1 more source

Clinical outcome of endoscopic hemostasis with heater probe coagulation for bleeding gastric ulcer

, 2014
Yoshihiro Inoué, Yasuhisa Fujino, Makoto Onodera, Satoshi Kikuchi, Masayuki Sato, Hisaho Sato, Hironobu Noda, Masahiro Kojika, Yasushi Suzuki, Shigeatsu Endo   +9 more
openalex   +1 more source