Results 61 to 70 of about 5,351 (216)

PDK4 and nutrient responses explain muscle specific manifestation in mitochondrial disease

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Mitochondrial disease triggers opposite responses in different muscles. Mitochondrial integrated stress response (ISRmt) and aerobic glycolysis characterize large muscles. Eye muscles show no ISRmt but activate PDK4—inhibitor of glucose oxidation—thereby upregulating beta‐oxidation, which is non‐optimal in mitochondrial disease and can explain eye ...
Swagat Pradhan, Takayuki Mito, Nahid A Khan, Sofiia Olander, Aleksandra Zhaivoron, Thomas G McWilliams, Anu Suomalainen   +6 more
wiley   +1 more source

Journey of frontalis muscle advancement in severe blepharoptosis: Review of the techniques, modifications, and outcomes

Indian Journal of Ophthalmology
We aimed to review the degree of standardization of frontalis muscle (FM)–orbicularis muscle advancement techniques in the management of severe congenital blepharoptosis and also study the evidence which supports the procedure correcting blepharoptosis ...
Kasturi Bhattacharjee, Komal Sawarkar, Deepak Soni, Gargi Wavikar   +3 more
doaj   +1 more source

Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis [PDF]

, 2016
Dedifferentiated chondrosarcoma (DDCS) is a rare disease with a dismal prognosis. DDCS consists of two morphologically distinct components: the cartilaginous and noncartilaginous components.
Cao, Dengfeng, Chen, Rongrong, Chen, Xi, DeLaney, Thomas F, Gao, Lu, Gao, Xiaohuan, Gong, Xinqi, Guo, Xiaopeng, Hong, Xiafei, Ni, Jianjiao, Tian, Pangzehuan, Wang, Renzhi, Xing, Bing, Yao, Yong   +13 more
core   +2 more sources

OXA1L deficiency causes mitochondrial myopathy via reactive oxygen species regulated nuclear factor kappa B signalling pathway

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
OXA1L gene bi‐allelic variants cause mitochondrial myopathy. OXA1L deficiency results in combined mitochondrial respiratory chain defects and OXPHOS impairments. OXA1L deficiency leads to elevated ROS production, which may activate the NF‐κB signalling pathway, disturbing myogenic gene expression and triggering cell apoptosis. Abstract Background OXA1L
Yongkun Zhan, Qian Wang, Ya Wang, Yanjie Fan, Dan Yan, Xianlong Lin, Yaoting Chen, Tingting Hu, Nan Li, Weiqian Dai, Hezhi Fang, Yongguo Yu   +11 more
wiley   +1 more source

Nursing management of a patient with oculomotor nerve paralysis caused by systemic lupus erythematosus (1例系统性红斑狼疮致动眼神经麻痹患者护理体会)

中西医结合护理, 2022
This paper summarized the whole process of nursing intervention for a patient with oculomotor paralysis caused by systemic lupus erythematosus. Responsible nurses were involved throughout the process, in which overall evaluation of disease condition ...
LI Yuncui (李运翠), TANG Ling (唐玲), HU Hairong (胡海荣), PENG Dan (彭丹), QI Wenjing (綦文婧)   +4 more
doaj   +1 more source

Is refraction with a hand-held autorefractometer useful in addition to visual acuity testing and questionnaires in preschool vision screening at 3.5 years in Japan? [PDF]

, 2009
The vision-screening program for 3.5-year-old children in Japan consists of 3 steps:questionnaires and home visual acuity testing, visual acuity testing by nurses and inspection by medical officers at regional Public Health Centers, and examinations by ...
Ichiba, Naofumi, Kio, Keiko, Matsuo, Chie, Matsuo, Toshihiko, Matsuoka, Hiroaki   +4 more
core   +1 more source

Observation of Safety and Efficacy of Botulinum Toxin Type A in the Treatment of Tear Troughs and Mild Yelid Bags

Journal of Cosmetic Dermatology, Volume 24, Issue 6, June 2025.
ABSTRACT Objective To evaluate the safety and efficacy of Botulinum Toxin Type A (BTX‐A) injection for the treatment of tear troughs. Method This study included patients with tear troughs rated as Grade 1–2 on the Barton Aesthetic Scale, who were treated between September 2023 and September 2024.
Siyuan Zhou, Homgtao Liu, Zhongjie Pan, Fuqiang Pan, Qian Liang, Houhuang Qiu, Bingliang Wu, Liming Zhang, Xiang Zhou   +8 more
wiley   +1 more source

Stereoscopic Three-Dimensional Images of an Anatomical Dissection of the Eyeball and Orbit for Educational Purposes [PDF]

, 2013
The purpose of this study was to develop a series of stereoscopic anatomical images of the eye and orbit for use in the curricula of medical schools and residency programs in ophthalmology and other specialties.
Matsuo, Toshihiko, Ohtsuka, Aiji, Takeda, Yoshimasa   +2 more
core   +1 more source

Presentation and Outcomes of Localized Immunoglobulin Light Chain Amyloidosis: 14‐Year Experience of an Academic Center

Hematological Oncology, Volume 43, Issue 3, May 2025.
ABSTRACT Localized light chain amyloidosis (loc‐AL) is a rare disorder characterized by localized deposition of misfolded AL fibrils. There are limited data on patterns of disease presentation and long‐term outcomes. In this study, we retrospectively reviewed 146 patients with loc‐AL at our institution between January 1, 2010, and March 1, 2024.
Danai Dima, Utkarsh Goel, Fauzia Ullah, Beth Faiman, Diana Basali, Sandra Mazzoni, Louis S. Williams, Christy Samaras, Jason Valent, Faiz Anwer, Jack Khouri, Shahzad Raza   +11 more
wiley   +1 more source

Correction of congenital ptosis of the eyelid by frontal muscle transposition [PDF]

Vojnosanitetski Pregled, 2002
Congenital ptosis (CP) represents a significant reconstructive problem Numerous studies have not yet provided full and satisfactory results. In this study, we have presented our experience in the surgical treatment of 108 patients by the use of Son Ye ...
Jevtović Dobrica
doaj   +1 more source