Results 101 to 110 of about 395,678 (332)

The Brain Drain: an Unmitigated Blessing? [PDF]

open access: yes
Increasingly, immigration policies tend to favour the entry of skilled workers, raising substantial concerns among sending countries. The “revisionist” approach to the analysis of the brain drain holds that such concerns are largely unwarranted.
Riccardo Faini
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

The Dominicans in History [PDF]

open access: yes, 1916
Father Schweriner, O.P., highlights the history of the Dominican Order from the time St. Dominic received the Papal Blessing for his vision of Christ’s work on earth through to the Order’s expansion during the Middle Ages – to the development of the ...
Schweriner, O.P., Thomas M.
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

A Spiritual Theology of the Conscience: An Extraordinary Force of Grace

open access: yesReligions
This article invites reflection upon the spiritual theological nature of the conscience as a means to discern God’s word in the depths of the soul. Coming from the depths of love and truth, the conscience is an extraordinary, demanding the force of grace.
Glenn Morrison
doaj   +1 more source

COVID19 - A Daredevil or A Blessing In Disguise

open access: diamond, 2020
Inayat Thaver   +2 more
openalex   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Požehnání v biblické a prakticko-teologické perspektivě: Příspěvek k diskuzi o žehnání párů stejného pohlaví

open access: yesTeologická Reflexe
The study examines the concept and practice of blessing in contemporary Christian churches and reflects on the possibilities of blessing same-sex couples.
Tabita Landová
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Festo: Blessing to Patent Holders or Thorn in Their Sides? [PDF]

open access: yes, 2002
The Supreme Court makes another attempt to strike a balance between protecting an inventor\u27s patent rights and ensuring adequate notice to the public of what constitutes patent infringement. This iBrief discusses the Supreme Court ruling in Festo Corp.
Miller, Jennifer
core   +1 more source

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