Results 191 to 200 of about 395,678 (332)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Cervical spine schwannomas in a young female from a low resource setting: a case report. [PDF]

open access: yesJ Med Case Rep
Ssembatya JM   +9 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

የምርቃን ስርዓተ ከበራ ኃይል በሰሜን ወሎ ማኅበረሰብ

open access: yesJournal of Ethiopian Studies
የዚህ ጥናት ዋና ዓላማ የምርቃን ስርዓተ ከበራ የሚያስገኘውን ማኅበረ-ስነልቦናዊ ፋይዳ መመርመር ነው፡፡ ስለሆነም የሰሜን ወሎ ማኅበረሰብን  ፍልስፍና፣ አስተሳሰብ እንዲሁም አመለካከት ለመረዳት ላቅ ያለ  ሚና ይኖረዋል፡፡ ጥናቱ በባህርይው  ከአይነታዊ ምርምር የሚዋገን  ነው፡፡ በተለያዩ መስፈርቶች ከተመረጡ የመረጃ አቀባዮች በምልከታ ፣ በቃለ መጠይቅ እንዲሁም በቡድን ውይይት የመረጃ መሰብሰቢያ ...
Demis Meshesha
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

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