Results 41 to 50 of about 391,996 (337)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Kur'an Bütünlüğü İçinde Mal ve İnsan ilişkisi

open access: yesCumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2007
Kur'an mala karşı olumsuz bir tavır almamakta ve onun aleyhindetbir hükürri, bir ifade kullanmamaktadır. Kur'an, genel olarak insanın ina! ve mülk edinmesine olumlu bakmaktadır.
Nihat TEMEL
doaj  

University libraries in a changing environment: experiences and the way forward in the new e-learning environment in Zimbabwe [PDF]

open access: yes, 2008
The paper looks at the reasons prompting academic librarians to embrace e-learning and the benefits that can be derived from using electronic information services.
Chiparausha, Blessing   +1 more
core  

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

A Hermeneutics of Blessing as a Meta-Requisite for Reconciliation: John E. Toews’ Romans Paradigm as a Case Study [PDF]

open access: yes, 2010
Within an overall framework of reconciliation as a transformation of mimetic structures of violence to mimetic structures of blessing, teachings of blessing are needed throughout the process. “Teachings” are considered as paradigmatic stories, principles,
Redekop, Vern Neufeld
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

“May God preserve us from evil sicknesses”: Grammar, Arabic origin, and pragmatics of request prayers in Bambara (Mande)

open access: yesLinguistique et Langues Africaines
Dùgawu, petitionary or request prayers, are ubiquitous in the lives of Bambara speakers. Leave-taking or good-night wishes, wishes of success, of quick recovery to a sick person, encouragement to accomplish a difficult task, the expressions of ...
Klaudia Dombrowsky-Hahn, Francesco Zappa
doaj   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

open access: yesFEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera   +4 more
wiley   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

open access: yesFEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

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