Results 171 to 180 of about 24,066 (248)

Advanced radiomics techniques applied on carotid duplex ultrasound data predict adverse outcomes in acute ischemic stroke. [PDF]

Front Neurol
Zhang L, Cao H, Miao L, Zhang X, Shi G.
europepmc   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Protocol for BASE: a multicentre, double-blind, randomised, controlled trial of bupropion hydrochloride in acute ischaemic stroke in China. [PDF]

BMJ Open
Cheng Q, Ran Y, Wang D, Yang W, Shen Y, Ren Y, Zhang H, Xiang Y, Wang H, Wang J, Guo J, Wu C, Chen S, Li H, Li W, Zhang P, Liu D, Zhou Q, Li Q, Zheng P, Hu Z, Xie P.   +21 more
europepmc   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Perforated Meckel's diverticulum: A rare evolution from diverticulitis to sepsis. [PDF]

Radiol Case Rep
Montatore M, Capasso MG, Masino F, Balbino M, Guglielmi G.   +4 more
europepmc   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Adjuvant Therapy for High-Risk Stage II Cutaneous Melanoma: Insights and Future Directions. [PDF]

Cancers (Basel)
Pravisano F, Costa J, Marchi L, Pascoletti G, Poletto E, Del Vecchio M, Spagnoletti A, Cimminiello C, Papadopoulos N, Pigozzo J, Piccin L, Roccuzzo G, Fava P, Puglisi F, Aprile G, Minisini AM.   +15 more
europepmc   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Protocol of the PANEM trial: A randomized, phase III, parallel-arm, placebo-controlled, double-blind, multi-center superiority trial comparing PANcreatic EnzyMes versus placebo in adults after gastrectomy. [PDF]

PLoS One
Thomas K, Ackmann C, Schmiedeknecht A, Scheibe K, Kleemann T, Ardelt M, Dondorf F, Radulova-Mauersberger O, Kuvendjiska J, Hipp J, Jansen-Winkeln B, Bley T, Wetzold U, Sporn J, Peters F, Téoule P, Birgin E, Petroff D, Hoffmeister A.   +18 more
europepmc   +1 more source