Results 61 to 70 of about 2,900,353 (313)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Körü Körüne İnanç Kriz ve Terör Dönemlerinde Geniş Gruplar ve Liderleri, yazar Vamık D. Volkan, çeviren Özgür Karaçam (İstanbul: Asi Kitap, 2017)

open access: yesCumhuriyet İlahiyat Dergisi, 2017
Dünya devletlerinin ortak sorunu olarak ele alabileceğimiz terör, birden fazla unsurun etkileşiminin ürünü olmakla birlikte ortaya çıkışında psikolojinin etkin olarak kullanıldığı, evrensel bir problemdir.
Gülşen Sayın
doaj  

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

A New Crack in the Wall of Mutual Recognition and Mutual Trust: Ne Bis in Idem and the Notion of Final Decision Determining the Merits of the Case

open access: yesEuropean Papers, 2017
(Series Information) European Papers - A Journal on Law and Integration, 2016 1(3), 1183-1193 | European Forum Insight of 5 January 2017 | (Table of Contents) I.
Stefano Montaldo
doaj   +1 more source

Dynamic Trust Federation in Grids

open access: yes, 2006
Grids are becoming economically viable and productive tools. Grids provide a way of utilizing a vast array of linked resources such as computing systems, databases and services online within Virtual Organizations (VO). However, today’s Grid architectures
Mehran Ahsant   +14 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han   +8 more
wiley   +1 more source

Oxytocin enhances social persuasion during hypnosis. [PDF]

open access: yesPLoS ONE, 2013
It has long been argued that hypnosis cannot promote behaviors that people will not otherwise engage in. Oxytocin can enhance trust in others, and may promote the extent to which a hypnotized person complies with the suggestion of a hypnotist.
Richard A Bryant, Lynette Hung
doaj   +1 more source

A record of friendly service to the blind, 1923-1940

open access: yes, 2023
This pamphlet details the endeavors of the Toledo Society for the Blind, in Toledo, Ohio, for the years 1923 through 1940. It includes the history, organization, activities, services rendered, and bequests.
Toledo Society for the Blind (Toledo, Ohio)
core  

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