Frailty Exacerbates Disability in Progressive Multiple Sclerosis
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks +10 more
wiley +1 more source
Age‐related macular degeneration (AMD) is a major cause of vision loss in the elderly, with limited oral treatment options for the wet form characterized by choroidal neovascularization (CNV).
Hyun Chul Jeong +4 more
doaj +1 more source
Application of the ex-Gaussian function to the effect of the word blindness suggestion on Stroop task performance suggests no word blindness [PDF]
The aim of the present paper was to apply the ex-Gaussian function to data reported by Parris et al. (2012) given its utility in studies involving the Stroop task. Parris et al.
Dienes, Zoltan +2 more
core +2 more sources
Efficacy and safety of zuranolone in Japanese adults with major depressive disorder: A double‐blind, randomized, placebo‐controlled, phase 2 clinical trial [PDF]
Masaki Kato +8 more
openalex +1 more source
Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin +2 more
wiley +1 more source
Developing Successful Global Health Alliances [PDF]
Examines the circumstances that call for alliance formation to reduce the burdens of AIDS, tuberculosis, malaria, polio, river blindness, and many other diseases; the utility of various alliance models; and the characteristics of successful ...
core
Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen +11 more
wiley +1 more source
The dialectic between marginal-central, as a system of representations, is created electively through the body, and the dialogue between the observer and the observed subject in an inter-subjective process of recognition; art it is a privileged area of ...
Nicoletta Agostini
doaj +1 more source
Detection of Hard Exudates in Retinal Fundus Images using Deep Learning
Diabetic Retinopathy (DR) is a retinal disorder that affects the people having diabetes mellitus for a long time (20 years). DR is one of the main reasons for the preventable blindness all over the world. If not detected early the patient may progress to
Benzamin, Avula, Chakraborty, Chandan
core +1 more source
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source

