Results 141 to 150 of about 2,917,992 (321)

Singularity classification as a design tool for multiblock grids [PDF]

A major stumbling block in interactive design of 3-D multiblock grids is the difficulty of visualizing the design as a whole. One way to make this visualization task easier is to focus, at least in early design stages, on an aspect of the grid which is ...
Jones, Alan K.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Collaborative block design task for assessing pair performance in virtual reality and reality. [PDF]

Heliyon, 2020
Wikström V, Martikainen S, Falcon M, Ruistola J, Saarikivi K.   +4 more
europepmc   +1 more source

Design and evaluation of artificial receptors for the reversal of neuromuscular block

, 2017
Tamás Sohajda, Ákos Fábián, Kata Tuza, Milo Malanga, Gábor Benkovics, Béla Fülesdi, E. Tassonyi, Lajos Szente   +7 more
openalex   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Enabling data-driven design of block copolymer self-assembly

Scientific Data
Here we present a database composed of scanning electron microscope images of self-assembled block copolymers. The fabrication process parameters, structural properties and microscope information are all contained in the image metadata, making a group of
Chiara Magosso, Irdi Murataj, Michele Perego, Gabriele Seguini, Debra J. Audus, Gianluca Milano, Federico Ferrarese Lupi   +6 more
doaj   +1 more source

Designing for Cooler Street: Case Study of Van City

Land
In the context of global climate change and rapid urbanization, the Urban Heat Island (UHI) effect has become a pressing environmental and public health concern, particularly in semiarid regions.
Nursevil Yuca, Şevket Alp, Sevgi Yilmaz, Elmira Jamei, Adeb Qaid   +4 more
doaj   +1 more source

Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions [PDF]

, 2019
Yuan Zhang, Xin Meng, Haikang Tang, Minghui Cheng, Fujun Yang, Wenqing Xu   +5 more
openalex   +1 more source

Design of a photo-activatable ivabradine to enable light induced block of HCN current in tissues [PDF]

, 2023
Alessandro Porro, Cristiano Bolchi, Federico Brandalise, Rebecca Appiani, R. Leone, Federico Thei, Gerhard Thiel, M. Pallavicini, Anna Moroni   +8 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source