Results 181 to 190 of about 113,837 (311)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Experiences with incomplete block designs in Denmark
, 2003 Incomplete block designs were first used in the statutory variety trials in Denmark in 1979. During the last years the use of incomplete block designs in variety trials has increased and is now used both for performance trials and DUS trials in most of ...
Kristensen, Kristian, Willads, Jakob
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Blocked Two-Level Regular Designs with Individual Aliased Effect Number Pattern. [PDF]
Entropy (Basel)Han M, Zhao S, Sun T.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Experimental Designs for Preclinical Neuroscience Experiments: Part 2-Blocking and Blocked Designs. [PDF]
eNeuroReynolds PS.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Reinforced block designs with standards
Our aim is to present some new procedures for constructing the reinforced block designs introduced by Das (1958). This work contributes to the theory of connected block designs supplemented by one or more additional treatments and blocks.
Krzyszkowska, Jolanta +2 more
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, 1977 The construction and analysis of a class of supplemented block designs which are partially efficiency balanced (Puri and Nigam, 1976) have been discussed.
Nigam, A. K., Narain, P., Puri, P. D.
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