Results 221 to 230 of about 724,525 (268)

Modified vedic multiplier architecture using Nikhilam and Karatsuba algorithms with hybrid adders for enhanced performance. [PDF]

Sci Rep
A S, A S.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

UNet with self-adaptive Mamba-like attention and causal-resonance learning for medical image segmentation. [PDF]

Sci Rep
Qamar S, Fazil M, Ahmad P, Khan S, Zamani AT.   +4 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

PCORnet®: An Infrastructure Supporting Innovation in Clinical Study Design. [PDF]

Med Care
Hernandez AF, Shenkman E, McTigue K, Kepler L, Cohen LW, Jolles MP, Rothman RL, Block JP, Carton TW, Tobin J, Priest EL, Evans C, Heintzman J, Williams DA.   +13 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Design of low power energy efficient sigma-delta ADC for biomedical IoT applications. [PDF]

Sci Rep
Sharma BP, Gupta A, Shekhar C, Chauhan R, Chamola V.   +4 more
europepmc   +1 more source

A novel and optimized design of D-latch and D flip-flop for QCA-based digital systems. [PDF]

Sci Rep
Vosta PK, Gholami M.
europepmc   +1 more source

Robust and compact reversible logic gate for low-power and high-performance computing. [PDF]

Sci Rep
Rajput A, Kumawat R, Srinivasulu A, Sharma J.   +3 more
europepmc   +1 more source