Results 31 to 40 of about 425,063 (266)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

On Factorization and Calculation of Determinant of Block Matrices with Triangular Submatrices

open access: yesJournal of New Theory
In this paper, we consider some block matrices of dimension $nm\times{nm}$ whose components are triangular matrices of dimension $n\times{n}$. We prove that the determinant of such block matrices is determined only by the diagonal elements of their ...
Fatma Altun, Ufuk Kaya
doaj   +1 more source

Optimal Backward Perturbation Analysis for the Block Skew Circulant Linear Systems with Skew Circulant Blocks

open access: yesAbstract and Applied Analysis, 2014
We first give the block style spectral decomposition of arbitrary block skew circulant matrix with skew circulant blocks. Secondly, we obtain the singular value of block skew circulant matrix with skew circulant blocks as well.
Zhaolin Jiang, Juan Li, Jianwei Zhou
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Analysis of the impact on the gravity field determination from the data with the ununiform noise distribution using block-diagonal least squares method

open access: yesGeodesy and Geodynamics, 2016
The block-diagonal least squares method, which theoretically has specific requirements for the observation data and the spatial distribution of its precision, plays an important role in ultra-high degree gravity field determination. On the basis of block-
Wei Liang   +3 more
doaj   +1 more source

Deficiency indices of block Jacobi matrices and Miura transformation

open access: yesSpecial Matrices, 2022
We study the infinite Jacobi block matrices under the discrete Miura-type transformations which relate matrix Volterra and Toda lattice systems to each other and the situations when the deficiency indices of the corresponding operators are the same.
Osipov Andrey
doaj   +1 more source

On similarity of an arbitrary matrix to a block diagonal matrix

open access: yesFilomat, 2021
Let an n x n -matrix A have m < n (m ? 2) different eigenvalues ?j of the algebraic multiplicity ?j (j = 1,..., m). It is proved that there are ?j x ?j-matrices Aj, each of which has a unique eigenvalue ?j, such that A is similar to the block-diagonal matrix ?D = diag (A1,A2,..., Am). I.e. there is an invertible matrix T, such that T-1AT
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

A Note on the Eigenvalue Analysis of the SIMPLE Preconditioning for Incompressible Flow

open access: yesJournal of Applied Mathematics, 2012
We consider the SIMPLE preconditioning for block two-by-two generalized saddle point problems; this is the general nonsymmetric, nonsingular case where the (1,2) block needs not to equal the transposed (2,1) block, and the (2,2) block may not be zero ...
Shi-Liang Wu, Feng Chen, Xiao-Qi Niu
doaj   +1 more source

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