Results 21 to 30 of about 76,394 (200)
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
The structure of blocks with a Klein four defect group [PDF]
, 2011 We prove Erdmann’s conjecture [16] stating that every block with a Klein four defect group has a simple module with trivial source, and deduce from this that Puig’s finiteness conjecture holds for source algebras of blocks with a Klein four defect group.
A. Borel +44 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Algebraic properties of generalized Rijndael-like ciphers [PDF]
, 2012 We provide conditions under which the set of Rijndael functions considered as permutations of the state space and based on operations of the finite field $\GF (p^k)$ ($p\geq 2$ a prime number) is not closed under functional composition.
B. Scott +5 more
core
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Enhanced Recursive Reed-Muller Erasure Decoding [PDF]
, 2016 Recent work have shown that Reed-Muller (RM) codes achieve the erasure channel capacity. However, this performance is obtained with maximum-likelihood decoding which can be costly for practical applications. In this paper, we propose an encoding/decoding
Cunche, Mathieu +4 more
core +5 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Pairwise transitive 2-designs [PDF]
, 2015 We classify the pairwise transitive 2-designs, that is, 2-designs such that a group of automorphisms is transitive on the following five sets of ordered pairs: point-pairs, incident point-block pairs, non-incident point-block pairs, intersecting block ...
Devillers, Alice, Praeger, Cheryl E.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Infinity-Norm Permutation Covering Codes from Cyclic Groups
, 2017 We study covering codes of permutations with the $\ell_\infty$-metric. We provide a general code construction, which uses smaller building-block codes.
Karni, Ronen, Schwartz, Moshe
core +1 more source